A near-complete genome assembly of Catharanthus roseus and insights into its vinblastine biosynthesis and high susceptibility to the Huanglongbing pathogen  

作　　者：Zhongping Xu Guanying Wang Qiongqiong Wang Xiaoting Li Guangyu Zhang Ali Qurban Can Zhang Yi Zhou Huan Si Lisong Hu Fuqiu Wang Ying Wang Zhitao Tian Wei Chen Shuangxia Jin Fang Ding 

机构地区：[1]Hubei Key Laboratory of Plant Pathology,College of Plant Science and Technology,Huazhong Agricultural University,Wuhan,Hubei,China [2]National Key Laboratory of Crop Genetic Improvement,Huazhong Agricultural University,Wuhan,Hubei,China [3]Tobacco Research Institute,Chinese Academy of Agricultural Sciences,Qingdao,Shandong,China [4]Spice and Beverage Research Institute,Chinese Academy of Tropical Agricultural Sciences,Wanning,Hainan,China [5]National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research(Wuhan),Huazhong Agricultural University,Wuhan,Hubei,China [6]Key Laboratory of Horticultural Plant Biology of MOE(Ministry of Education),Huazhong Agricultural University,Wuhan,Hubei,China

出　　处：《Plant Communications》2023年第6期216-220,共5页植物通讯（英文）

基　　金：supported by grants from the National Natural Science Foundation of China(31872077);the National Key Research and Development Program of China(2021YFD1400800);Special Projects for Foreign Cooperation of Yunnan Province(no.202003AD150014)to F.D.

摘　　要：Dear Editor,Catharanthus roseus,an important medicinal plant native to Madagascar,is the sole source of the two important anticancer drugs vinblastine and vincristine,which are synthesized by the monoterpene-derived indole alkaloid(MIA)pathway(Das et al.,2020).It is also an important model plant for the study of Huanglongbing(HLB),a devastating citrus disease that causes severe economic losses worldwide(Ma et al.,2022).Vincristine is an FDA-approved drug that has been used for acute lymphocytic leukemia,lymphoid blast crisis of chronic myeloid leukemia,and Hodgkin’s/non-Hodgkin’s lymphoma(Below and M Das,2021).

关 键 词：drugs LYMPHOCYTIC 

分 类 号：Q94[生物学—植物学]