Engineering a plant A-to-K base editor with improved performance by fusion with a transactivation module  

作　　者：Yucai Li Shaoya Li Chenfei Li Chen Zhang Lei Yan Jingying Li Yubing He Yan Guo Yong Lin Yangjun Zhang Lanqin Xia 

机构地区：[1]Institute of Crop Sciences(ICS),Chinese Academy of Agricultural Sciences(CAAS),Beijing 100081,China [2]Hainan Yazhou Bay Seed Laboratory/National Nanfan Research Institute(Sanya),CAAS,Sanya,Hainan Province 572024,China [3]State Key Laboratory of Plant Physiology and Biochemistry,College of Biological Sciences,China Agricultural University,Beijing 100193,China [4]Beijing Dabeinong Technology Group Co.,Ltd.,Beijing 10080,China

出　　处：《Plant Communications》2023年第6期225-229,共5页植物通讯（英文）

基　　金：funded by the National Natural Science Foundation of China(grant no.32188102 to L.X.);the Hainan Yazhou Bay Seed Lab(grant no.B23CJ0208 to L.X.);the Central Publicinterest Scientific Institution-Based Research Fund(grant no.ZDXM2308 to L.X.);the National Engineering Research Centre of Crop Molecular Breeding.

摘　　要：Dear Editor,Base editors(BEs)are promising tools that enable single-nucleotide substitutions in specific target genes,generating loss-offunction or gain-of-function mutations,which can greatly accelerate plant functional genomics and crop improvement(Ren et al.,2018;Zeng et al.,2020;Xu et al.,2021;Yan et al.,2021;Li et al.,2023).To date,three major classes of BEs have been engineered:cytosine BEs(CBEs)for C-to-T transitions(Komor et al.,2016),adenine BEs(ABEs)for A-to-G transitions(Gaudelli et al.,2017).

关 键 词：CBE EDITOR BASE 

分 类 号：Q94[生物学—植物学]