石氏温经宣痹通络汤治疗风寒湿痹型膝关节骨性关节炎的临床疗效  

Clinical effect of ShishiWenjing Xuanbi Tongluo decoction onWind-cold-dampness arthritis of knee joint

作　　者：余益群 吴军豪 闻国伟 吴海洋 屠安琪 张吉仁 YU Yiqun;WU Junhao;WEN Guowei;WU Haiyang;TU Anqi;ZHANG Jiren(Department of TCM Orthopedicsand Traumatology,Huangpu Branch of the Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai,200011,China)

机构地区：[1]上海交通大学医学院附属第九人民医院黄浦分院中医骨伤科,上海200011

出　　处：《当代医学》2024年第2期73-77,共5页Contemporary Medicine

摘　　要：目的探讨石氏温经宣痹通络汤治疗膝关节骨性关节炎的临床疗效。方法选取2019年3月至2020年4月上海交通大学医学院附属第九人民医院黄浦分院收治的144例风寒湿痹型膝关节骨性关节炎患者作为研究对象,按照随机数字表法分为治疗组与对照组,每组72例。治疗组给予石氏温经宣痹通络汤治疗,对照组给予西乐葆胶囊治疗,比较两组治疗前后西安大略和麦克马斯特大学骨关节炎指数(WOMAC)评分变化、临床疗效及不良反应发生情况。结果组间比较:治疗前,两组WOMAC疼痛评分、僵硬评分、膝关节功能评分比较差异无统计学意义;治疗组治疗7、14 d的WOMAC疼痛评分均高于对照组,治疗28 d、随访8周的WOMAC疼痛评分均低于对照组,差异有统计学意义(P<0.05);治疗组治疗7、14、28 d及随访8周的WOMAC僵硬评分均低于对照组,差异有统计学意义(P<0.05);治疗组治疗7 d的WOMAC膝关节功能评分高于对照组,治疗14、28 d及随访8周的WOMAC膝关节功能评分低于对照组,差异有统计学意义(P<0.05)。治疗组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论石氏温经宣痹通络汤用于治疗风寒湿痹型膝关节骨性关节炎疗效显著,可减轻患者膝关节疼痛,改善膝关节功能,且安全性较高。Objective To explore the efficacy of Shishi Wenjing Xuanbi Tongluo decoction on Wind-cold-dampness arthritis of knee joint.Methods A total of 144 patients with Wind-cold-dampness arthritis of knee joint admitted to Huangpu Branch of the Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine from March 2019 to April 2020 were selected as the research subjects,and they were divided into the treatment group and the control group according to random number table method,with 72 cases in each group.The treatment group was given Shishi Wenjing Xuanbi Tongluo decoction,and the control group was given xielebao capsule,the changes of Western Ontario and McMaster University osteoarthritis index(WOMAC)scores before and after treatment,clinical efficacy and adverse reactions were compared between the two groups.Results Comparison between groups:before treatment,there were no significant differences in WOMAC pain score,stiffness score and knee function score between the two groups;the WOMAC pain scores in the treatment group were higher than those in the control group at 7 and 14 d of treatment,and the WOMAC pain scores were lower than those in the control group at 28 d in treatment and 8 weeks of follow-up,the differences were statistically significant(P<0.05);the WOMAC stiffness scores in the treatment group were lower than those in the control group at 7,14,28 d of treatment and 8 weeks of follow-up,and the differences were statistically significant(P<0.05);the WOMAC knee function score in the treatment group was higher than that in the control group at 7 d of treatment,and the WOMAC knee function score were lower than those in the control group at 14,28 d in treatment and 8 weeks of follow-up,the differences were statistically significant(P<0.05).The total effective rate in the treatment group was higher than that in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.Concl

关 键 词：石氏温经宣痹通络汤 膝骨关节炎 风寒湿痹型 

分 类 号：R593.22[医药卫生—内科学]