银翘散联合磷酸奥司他韦治疗甲型流感的临床效果及对淋巴细胞亚群的影响  

Clinical efficacy of Yinqiao Powder combined with oseltamivir phosphate in the treatment of influenza Aand its impact on lymphocyte subsets

作　　者：杜亚哲 肖少伟 Du Yazhe;Xiao Shaowei(Department of Infectious Diseases,First People′s Hospital of Ruzhou,Pingdingshan,Henan 467599,China)

机构地区：[1]河南省汝州市第一人民医院感染性疾病科,河南平顶山467599

出　　处：《中国药物与临床》2024年第4期221-225,共5页Chinese Remedies & Clinics

摘　　要：目的分析甲型流感采用银翘散联合磷酸奥司他韦治疗的临床效果及治疗对淋巴细胞亚群的影响。方法将河南省汝州市第一人民医院2022年5月至2023年2月收治的98例甲型流感患儿按治疗方法分为对照组(49例)与试验组(49例),对照组行磷酸奥司他韦治疗,试验组行磷酸奥司他韦联合银翘散治疗,治疗周期为5 d。比较2组临床症状改善时间(病毒转阴时间、体温恢复时间、乏力缓解时间、咽痛消失时间)和不良反应,比较治疗前及治疗后3、5 d肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、C-反应蛋白(CRP)、白细胞介素-8(IL-8)水平以及治疗前及治疗5 d后咳嗽,头痛,乏力评分,CD4^(+)、CD8^(+)百分比,CD4^(+)/CD8^(+)比值。结果相较于对照组,试验组的病毒转阴时间、体温恢复时间、乏力缓解时间、咽痛消失时间均缩短(P<0.05);治疗后3、5 d 2组TNF-α、IL-6、CRP、IL-8水平与治疗前比较降低,试验组与对照组比较更低;治疗5 d后2组咳嗽、头痛、乏力评分及CD8^(+)百分比与治疗前比较降低,试验组与对照组比较更低,CD4^(+)百分比、CD4^(+)/CD8^(+)比值与治疗前比较升高,试验组与对照组比较更高(P<0.05)。治疗期间,对照组出现头晕、腹泻、皮疹、恶心呕吐各1例,试验组出现头晕、皮疹各1例,腹泻、恶心呕吐各2例,2组不良反应总发生率(8%与12%)比较差异无统计学意义(χ^(2)=0.445,P>0.05)。结论甲型流感采用银翘散联合磷酸奥司他韦治疗可缩短临床症状改善时间,减轻炎症反应,改善患儿临床症状,同时提高患儿免疫能力,促进患儿康复,且安全、可靠。Objective To analyze the clinical efficacy of Yinqiao powder combined with oseltamivir phosphate in the treatment of influenza A,and the impact of treatment on lymphocyte subsets.Methods A total of 98 children with influenza A admitted to the First People′s Hospital of Ruzhou in Henan Province from May 2022 to February 2023 were divided into a control group(49 cases)and an experimental group(49 cases)depending on treatment method.The control group received oseltamivir phosphate treatment,while the experimental group received oseltamivir phosphate and Yinqiao Powder treatment,with a treatment period of 5 days.The im-provement time of clinical symptoms(time for virus to turn negative,time for body temperature recovery,time for fatigue relief,time for pharyngeal pain disappearance)and adverse reactions,tumor necrosis factor before treat-ment and after 3 and 5 days of treatment for both groups-α(TNF-α),Compare the levels of interleukin-6(IL-6),C-reactive protein(CRP),interleukin-8(IL-8),cough,headache,fatigue scores,CD4^(+),CD8^(+)percentage,and CD4^(+)/CD8^(+)ratio before and after 5 days of treatment.Results Compared with the control group,the time of virus reversal,temperature recovery time,fatigue relief time,and throat loss time were shortened(P<0.05);TNF-α,IL-6,CRP,IL-8 levels decreased compared with before treatment after treatment 3 and 5 d;cough,headache,fatigue score and CD8^(+)percentage decreased after 5 d,CD4^(+)percentage,CD4^(+)/CD8^(+)ratio,and compared with control group(P<0.05).During the treatment period,there was 1 case of dizziness,diarrhea,rash,nausea and vomiting in the control group,1 case of dizziness and rash in the experimental group,and 2 cases of diarrhea,nausea and vomiting in the experimental group.There was no statistically significant difference in the total incidence of adverse reactions between the two groups(8%vs 12%,χ^(2)=0.445,P>0.05).Conclusion The use of Yinqiao Powder combined with oseltamivir phosphate in the treatment of influenza A can shorten the period of improvemen

关 键 词：多成分抗感冒、流感和过敏药 银翘散 奥司他韦 治疗结果 淋巴细胞亚群 

分 类 号：R511.7[医药卫生—内科学]