尿毒清颗粒结合血液透析对尿毒症肾功能、炎症指标改善作用研究  

Improvement of Renal Function and Inflammation Indexes of Uremia Patients by Niaoduqing Granules(尿毒清颗粒)Combined with Hemodialysis

作　　者：刘倩[1] 王晶[1] 霍鹏飞[1] 刘爱翔[1] 鲁华[1] LIU Qian;WANG Jing;HUO Pengfei;LIU Aixiang;LU Hua(Xingtai People's Hospital,Xingtai 054000,Hebei,China)

机构地区：[1]邢台市人民医院,河北邢台054000

出　　处：《中华中医药学刊》2024年第4期225-229,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：河北省科学技术厅项目(182777178)。

摘　　要：目的评价尿毒清颗粒结合血液透析对尿毒症患者肾功能、炎症指标的改善作用。方法选择2019年1月—2022年1月医院收治的136例尿毒症病人为试验对象,随机将其分成两组。所有患者入院后均给予低盐、低蛋白饮食,控制高血压,纠正贫血和营养不良等。对照组68例患者采用规律血液透析,选择费森4008S型血液透析机,枸橼酸盐透析液,透析血流量在260 mL/min,透析液流量500 mL/min,血液透析通道为颈内静脉,常规肝素抗凝,每周透析3次,每次4 h,连续治疗12周。治疗组68例采用尿毒清颗粒结合血液透析治疗,血液透析方法同对照组,口服尿毒清颗粒,连续治疗12周。比较两组治疗前后中医证候(神疲力乏、肢体沉重、气短懒言、腰膝酸软、脘腹胀满和肌肤甲错)积分变化,肾功能指标[血清尿素氮(Serum urea nitrogen,BUN)、血肌酐(Serum creatinine,SCr)、内生肌酐清除率(Endogenous creatinine clearance,CCr)和24 h尿蛋白定量]变化,炎症指标[转化生长因子-β(Transforming growth factor-β,TGF-β)、白细胞介素-6(interleukin-6,IL-6)和C反应蛋白(C-reactive protein,CRP)水平]变化,营养指标(血浆白蛋白、转铁蛋白和血红蛋白)变化。结果经过12周的治疗,治疗组中达到显效标准的有22例,占比32.35%,达到有效标准的有39例,占比57.35%,总有效人数为61例,占比89.70%。对照组中达到显效标准的有19例,占比27.94%,达到有效标准的有33例,占比48.53%,总有效人数为52例,占比76.47%。组间结果比较显示,治疗组治疗疗效优于对照组(P<0.05);相较于治疗前,治疗后两组病人神疲力乏、肢体沉重、气短懒言、腰膝酸软、脘腹胀满和肌肤甲错等证候积分下降,且治疗组病人的下降幅度较对照组高(P<0.05);相较于治疗前,治疗后两组病人肾功能方面的指标BUN、SCr和24 h尿蛋白定量水平下降,CCr的浓度水平相较于治疗前上升,且治疗组改变的幅度较对照组高(P<0.05);Objective To evaluate the effect of Niaoduqing Granules(尿毒清颗粒)combined with hemodialysis on renal function and inflammation in patients with uremia.Methods A total of 136 patients with uremia in the hospital from January 2019 to January 2022 which were selected as the research objects.All patients were random divided into two groups.Therefore,after admission,the patients were given a low-salt and low-protein diet to control hypertension and correct anemia and malnutrition.The control group(68 cases)was treated with regular hemodialysis,including Faisen 4008S hemodialysis machine,citrate hemodialysis fluid,hemodialysis blood flow of 260 mL/min,hemodialysis fluid flow of 500 mL/min.The hemodialysis was through the internal jugular vein,with routine heparin anticoagulation,3 times a week,4 h for each time.The continuous treatment lasted for 12 weeks.The treatment group(68 cases)used the stilbene capsule combined with Niaoduqing Granules.The hemodialysis method was the same as that of the control group.The treatment was continued for 12 weeks.The integral changes of traditional Chinese medicine syndromes(including fatigue,heavy limbs,shortness of breath and lazy speech,soreness of the waist and knees,fullness of the abdomen and abdomen,and skin nail errors),as well as changes in renal function indicators[serum urea nitrogen(BUN),serum creatinine(SCr),endogenous creatinine clearance(CCr),24-hour urine protein quantification],inflammatory indicators[transforming growth factor-β(TGF-β),changes in levels of interleukin-6(IL-6)and C-reactive protein(CRP)]as well as changes in nutritional indicators(plasma albumin,transferrin,hemoglobin)before and after treatment between the two groups were compared.Results After 12 weeks of treatment,there were 22 cases(32.35%)in the treatment group who met the obvious efficacy standard,and 39 cases(57.35%)who met the effective standard.The total number of effective cases was 61 cases(89.70%).In the control group,19 cases(27.94%)met the effective standard,while 33 cases(48.53%

关 键 词：尿毒清颗粒 血液透析 尿毒症 炎症因子 研究 

分 类 号：R277.592[医药卫生—中医学]