纳米材料在癌症氢治疗中的应用现状  

Application of Nanomaterials in Cancer Hydrogen Therapy

作　　者：欧阳瑞镯[1] 薛维锨 缪煜清[1] OUYANG Ruizhuo;XUE Weixian;MIAO Yuqing(University of Shanghai for Science and Technology,Shanghai 200093,China)

机构地区：[1]上海理工大学,上海200093

出　　处：《集成技术》2024年第1期82-95,共14页Journal of Integration Technology

基　　金：上海理工大学自设医工交叉项目(1022310503)。

摘　　要：氢气可以选择性地清除细胞毒性活性氧。在癌细胞内,氢气的存在会影响癌细胞内活性氧的平衡,从而使癌细胞凋亡。此外,与药物相比,氢气对人体清洁无害,对细胞膜的穿透性高,具有先天优势。然而,口服富氢水和注射富氢生理盐水等手段由于氢气在体内无目的性地扩散,难以实现良好的疗效。该文简要介绍了氢气治疗的机理,并通过列举目前的一些利用纳米材料进行氢气治疗的方法,介绍了氢治疗中,传递氢气的几种主要纳米系统,并对纳米材料在癌症氢治疗中的未来进行了展望。Hydrogen can selectively remove cytotoxic reactive oxygen species.The presence of hydrogen in cancer cells can affect the balance of reactive oxygen species in cancer cells,leading to apoptosis of cancer cells.In addition,hydrogen has innate advantages over drugs since it is harmless to the human body and can highly penetrate cell membranes.However,due to the diffusion of hydrogen in the body without purpose,it is difficult to achieve good curative effect by oral hydrogen-rich water and injection hydrogen-rich saline.In this paper,the mechanism of hydrogen therapy is briefly introduced,where two kinds of main nanosystems for hydrogen delivery in hydrogen therapy are introduced by enumerating some current methods of nanomaterials-based hydrogen therapy.In the end,the future of nanomaterials in cancer hydrogen therapy is prospected.

关 键 词：纳米材料 氢治疗 活性氧 原位产氢 纳米载体 癌症治疗 

分 类 号：O6[理学—化学]