低分子肝素对妊娠期高血压疾病患者血压水平及凝血酶时间、凝血酶原时间、部分活化凝血酶原时间的影响  

Analyzing the effects of low molecular weight heparin on blood pressure levels,thrombin time,prothrombin time,and partially activated prothrombin time in patients with gestational hypertension

作　　者：徐文丹 陈玲[1] Xu Wendan;Chen Ling(Department of Obstetrics,Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University,Nanjing 210004,China)

机构地区：[1]南京医科大学附属妇产医院产科,江苏南京210004

出　　处：《实用妇科内分泌电子杂志》2024年第3期68-70,共3页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的探讨低分子肝素对妊娠期高血压疾病患者血压水平和主要凝血指标的影响。方法选取本院76例妊娠期高血压疾病患者,按随机数字表法分为研究组和对照组,每组38例。对照组予以常规治疗,研究组在常规治疗基础上加用低分子肝素进行治疗,比较两组治疗前后的血压水平及凝血功能指标。结果研究组治疗总有效率为97.37%,高于对照组的84.21%,比较差异有统计学意义(P<0.05);治疗后,研究组收缩压、舒张压水平低于对照组(P<0.05);治疗后,研究组凝血酶时间、凝血酶原时间、部分活化凝血酶原时间长于对照组(P<0.05);研究组剖宫产、早产、新生儿窒息以及产后出血等发生率低于对照组(P<0.05);研究组药物不良反应率为5.26%,对照组为7.89%,比较差异无统计学意义(P>0.05)。结论对于妊娠期高血压疾病患者在治疗中给予低分子肝素能够获得确切疗效,有助于提升治疗总有效率,更好地控制患者血压水平及改善凝血功能指标,且有利于改善妊娠结局及用药安全性。objective To explore the effects of low molecular weight heparin on blood pressure levels and major coagulation indicators in patients with gestational hypertension.Methods 76 patients with gestational hypertension in our hospital were selected and randomly divided into an research group and a control group using a random number table method,with 38 cases in each group.The control group received routine treatment,while the research group received treatment with low molecular weight heparin in addition to routine treatment.The blood pressure levels and coagulation function indicators before and after treatment were compared between the two groups.Results The total effective rate of the research group was 97.37%,which was higher than the control group's 84.21%,and the difference was statistically significant(P<0.05);After treatment,the levels of systolic and diastolic blood pressure in the study group were lower than those in the control group(P<0.05);After treatment,the study group had longer thrombin time,prothrombin time,and partially activated prothrombin time than the control group(P<o.05);The incidence of cesarean section,premature birth,neonatal asphyxia,and postpartum hemorrhage in the research group was lower than that in the control group(P<0.05);The incidence of adverse drug reactions in the research group was 5.26%,while in the control group it was 7.89%,with no statistically significant difference(P>0.05).Conclusion For patients with gestational hypertension,administering low-molecular-weight heparin during treatment can achieve definite therapeutic effects,help improve overall treatment efficiency,better control patient blood pressure levels,improve coagulation function indicators,and improve pregnancy outcomes and medication safety.

关 键 词：妊娠期高血压疾病 低分子肝素 凝血指标 血压水平 

分 类 号：R714.246[医药卫生—妇产科学]