小剂量米非司酮用于更年期功能性子宫出血治疗的效果分析  

Effect analysis of low-dose mifepristone in the treatment of functional uterine bleeding during menopause

作　　者：胡迟秀 王彤辉 丁文 Hu Chixiu;Wang Tonghui;Ding Wen(Department of Pharmacy,Jiaozhou Central Hospital,Qingdao 266300,China)

机构地区：[1]山东省青岛市胶州中心医院药剂科,山东青岛266300

出　　处：《实用妇科内分泌电子杂志》2024年第3期74-76,共3页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的探究小剂量米非司酮治疗更年期功能性子宫出血(更年期功血)的实际疗效。方法选取58例更年期功血患者,按照抽签法将显示奇数的29例纳入基础组,显示偶数的29例纳入加用组。基础组予以基础戊酸雌二醇治疗,加用组在基础组的基础上加用小剂量米非司酮。对比两组治疗后的不良反应、临床有效率及性激素指标。结果治疗后,基础组与加用组不良反应比较差异无统计学意义(P>0.05)。加用组治疗总有效率为96.55%,高于基础组的72.41%,差异有统计学意义(P<0.05)。治疗1个月后,加用组临床性激素指标和子宫内膜厚度均优于基础组,差异有统计学意义(P<0.05)。结论更年期功血在小剂量米非司酮治疗下,具备巩固疗效、调节性激素水平和抑制子宫内膜增厚的作用,值得予以推广。Objective To explore the practical efficacy of low-dose mifepristone in the treatment of functional uterine bleeding during menopause(menopausal blood).Methods 58 patients with functional uterine bleeding during menopause were selected,and 29 patients with odd numbers were included in the basic group and 29 patients with even numbers were included in the additional group according to the drawing method.the basic group was treated with basic estradiol valerate,while the additional group received low-dose mifepristone in addition to the basic group.Compare the adverse reactions,clinical efficacy,and sex hormone indicators between the two groups after treatment.Results After treatment,there was no statistically significant difference in adverse reactions between the baseline group and the additional group(P>0.05).The total effective rate of the addition group was 96.55%,which was higher than 72.41%of the base group,and the difference was statistically significant(P<o.05).After one month of treatment,the clinical sex hormone indicators and endometrial thickness in the addition group were better than those in the base group,and the difference was statistically significant(P<0.05).Conclusion Under low-dose mifepristone treatment,functional uterine bleeding during menopause has the effects of consolidating therapeutic effects,regulating sex hormone levels,and inhibiting endometrial thickening,which is worth promoting.

关 键 词：更年期功能性子宫出血 小剂量米非司酮 戊酸雌二醇 性激素 

分 类 号：R711[医药卫生—妇产科学]