不孕合并宫内疾病患者慢性子宫内膜炎患病率及危险因素研究  

Study on the prevalence and risk factors of chronic endometritis in infertility patients with intrauterine diseases

作　　者：黄霄燕 莫小亮[2] 韦伟 刘茜茜 Huang Xiaoyan;Mo Xiaoliang;Wei Wei;Liu Qianqian(Center of Endocrinology and Metabolism,Wuming Hospital Affiliated to Guangxi Medical University,Nanning 530199,China;District 2,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China;Department of Gynecology Liuzhou People's Hospital,Liuzhou 545026,China)

机构地区：[1]广西医科大学附属武鸣医院妇科内分泌代谢中心,广西南宁530199 [2]广西医科大学第一附属医院妇二区,广西南宁530021 [3]柳州市人民医院妇科,广西柳州545026

出　　处：《实用妇科内分泌电子杂志》2024年第4期4-7,共4页Electronic Journal of Practical Gynecological Endocrinology

基　　金：广西医疗卫生适宜技术开发与推广应用项目(S2022076)。

摘　　要：目的探讨不孕合并宫内疾病患者慢性子宫内膜炎(CE)患病率,并分析其危险因素。方法选取478例不孕症患者为研究对象,将其有宫内疾病为研究组(n=369),无宫内疾病为对照组(n=109),术中收集患者子宫内膜样本,并进行CD38、CD138免疫组化染色以诊断CE,分析CE的患病率,通过单因素分析、多因素Logistic回归分析CE的危险因素。结果两组年龄、不孕年限、分娩次数比较差异有统计学意义(P<0.05);两组体质量指数(BMI)、怀孕次数比较差异无统计学意义(P>0.05);无宫内疾病、子宫内膜息肉、子宫黏膜下肌瘤、IUA、子宫憩室和纵隔子宫的患者中CE患病率分别为55.05%、63.04%、50.00%、56.83%、52.63%、42.86%,宫内疾病患者CE的患病率比较差异无统计学意义(P>0.05);无宫内疾病与宫内疾病的CE患者治疗后的妊娠率分别为20.00%、26.76%,差异无统计学意义(P>0.05)。多因素Logistic回归分析显示:子宫内膜息肉是CE的危险因素。结论子宫内膜息肉是CE的危险因素。CE对妊娠有影响,对于不孕症患者,有较高的CE患病率,建议在生育前均应给予治疗。Objective To investigate the prevalence of chronic endometritis(CE)in infertility patients with intrauterine diseases and analyze its risk factors.Methods A total of 478 infertility patients were selected as the study subjects,with intrauterine diseases as the study group(n=369)and without intrauterine diseases as the control group(n=109).Endometrial samples were collected during the operation,and CD38 and CD138 immunohistochemical staining were performed to diagnose CE and analyze the prevalence rate of CE.The risk factors of CE were analyzed by univariate analysis and multiple Logistic regression.Results There were significant differences in age,infertility years and delivery times between the two groups(P<0.05).There was no significant difference in body mass index(BMI)and pregnancy times between the two groups(P>0.05).The prevalence of CE in patients without intrauterine diseases,endometrial polyps,uterine submucous myoma,IUA,uterine diverticulum and mediastinal uterus was 55.05%,63.04%,50.00%,56.83%,52.63%and 42.86%,respectively.There was no significant difference in the prevalence of CE in patients with intrauterine diseases(P>0.05).The pregnancy rate of CE patients without intrauterine disease and those with intrauterine disease after treatment was 20.00%and 26.76%,respectively,with no statistical significance(P>0.05).Multivariate Logistic regression analysis showed that endometrial polyp was a risk factor for CE.Conclusion Endometrial polyps are the risk factors of CE.CE has an impact on pregnancy,and for infertility patients,there is a higher prevalence of CE,it is recommended that treatment should be given before childbirth.

关 键 词：慢性子宫内膜炎 不孕症 CD38/CD138 宫内疾病 子宫内膜息肉 

分 类 号：R711.6[医药卫生—妇产科学] R711.74[医药卫生—临床医学]