薯蓣皂苷治疗骨关节炎的研究进展  

Research Progress of Dioscin in the Treatment of Osteoarthritis

作　　者：刘霞 周本宏[1] LIU Xia;ZHOU Benhong(Department of Pharmacy,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院药学部,湖北武汉430060

出　　处：《特产研究》2024年第2期149-154,共6页Special Wild Economic Animal and Plant Research

摘　　要：薯蓣皂苷是一种植物来源甾体皂苷,具有抗癌、免疫调节、心血管保护等多种药理作用,早期研究已经证实,薯蓣皂苷可以用于骨关节炎(OA)的治疗。本文通过整理相关文献,对薯蓣皂苷治疗OA的相关机制进行总结和分析,包括对软骨细胞、成骨细胞、破骨细胞、软骨基质代谢调节,抑制炎症反应的研究,以期为薯蓣皂苷在OA方面的相关研究提供理论参考。Dioscin is a phytogenic steroid saponin,which has many pharmacological effects such as anti-cancer,immune regulation and cardiovascular protection.Early studies have confirmed that dioscin can be used in the treatment of osteoarthritis(OA).In this paper,we summarized and analyzed the relevant mechanisms of dioscin in the treatment of OA,including the regulation of the metabolism of chondrocytes,osteoblasts,osteoclasts and cartilage matrix,and the inhibition of inflammation,in order to provide theoretical reference for the relevant studies of dioscin in OA.

关 键 词：薯蓣皂苷 骨关节炎 软骨细胞 

分 类 号：R285.5[医药卫生—中药学]