基于ICRP新碘周身模型的滞留量计算及新旧模型差异对比  

Retention calculation and comparison between new and old model based on the ICRP new iodine biokinetic model

作　　者：代伟 王明[1,2] 董浪 张庆贤 谷懿[1,2] 曾国强[1,2] 李三刚[1,2] DAI Wei;WANG Ming;DONG Lang;ZHANG Qingxian;GU Yi;ZENG Guoqiang;LI Sangang(College of Nuclear Technology and Automation Engineering,Chengdu University of Technology,Chengdu 610059;Applied Nuclear Technology in Geosciences Key Laboratory of Sichuan Province(Chengdu University of Technology),Chengdu 610059)

机构地区：[1]成都理工大学核技术与自动化工程学院,成都610059 [2]地学核技术四川省重点实验室(成都理工大学),成都610059

出　　处：《辐射防护》2024年第2期110-119,共10页Radiation Protection

基　　金：四川省青年科学基金(No.2022NSFSC1185);2022年成都理工大学青年骨干教师发展计划(10912-JXGG2022-08667)。

摘　　要：国际放射防护委员会(ICRP)137号出版物对碘的生物动力学模型进行了修改,ICRP 100号出版物发布了新的消化道模型,ICRP 130号出版物修订了呼吸道模型,使用新模型计算出来的碘滞留量及排泄量与旧模型的计算结果存在差异。定量分析新旧模型的计算结果差异,可为国内准确评估放射性碘致内照射损伤提供参考。本文采用矩阵算法,依据ICRP相关出版物分别构建了新旧放射性碘生物动力学计算模型,系统分析了通过不同方式(吸入、食入、静脉注射)摄入1 Bq的^(125)I、^(129)I、^(131)I在甲状腺中的滞留量及在日排尿中的排泄量。此外,考虑到新模型划分了旧模型中没有的肝脏及肾脏隔室,也计算了碘同位素在肝脏及肾脏中的滞留量。结果表明:新旧模型计算出来的放射性碘在甲状腺以及日排尿中的计算结果均有明显差异;与食入和注射两种摄入方式相比,吸入方式引起计算结果差异较大;新模型中肝脏及肾脏中的滞留量计算结果有所不同,但变化趋势相似。One new detailed biokinetic model for systemic iodine has been published in the International Commission on Radiological Protection(ICRP)Publication No.137,which will lead to the calculation results of retention and excretion based on the new model that differs from the old iodine model.This paper aims to quantitatively analyze the difference in the calculation results of the old and new iodine system models,to provide a reference for the accurate assessment of radioactive iodine-induced internal exposure in China.In this paper,the matrix algorithm was used to build a calculation model of radioactive iodine based on ICRP publications,and the retention of radioactive iodine(including I-125,I-129,I-131)in thyroid and daily urine after intake through different ways(inhalation,ingestion and intravenous injection)was systematically analyzed.In addition,considering that the new model divides the liver and kidney parts that were not in the old model,the retention of radioactive iodine in these organs is also calculated and analyzed in this paper.The results showed that there were significant differences in the calculation results of radioactive iodine in the thyroid gland and daily urination calculated by the old and new models.But compared with ingestion and injection,the inhalation method could cause the largest difference in the calculation results.In the new model,the calculation results of retention in liver and kidney were different,but the variation tendency was similar.

关 键 词：碘周身模型 滞留量 排泄量 ICRP 137号出版物 

分 类 号：TL72[核科学技术—辐射防护及环境保护]