阿托伐他汀对2型糖尿病合并心脏自主神经病变患者氧化应激反应的影响  

Effect of Atorvastatin on oxidative stress in diabetes mellitus type 2 patients with cardiac autonomic neuropathy

作　　者：胡凤[1] 涂云明[1] 熊佳 HU Feng;TU Yunming;XIONG Jia(Department of General Medicine,the Fourth Affiliated Hospital of Nanchang University,Jiangxi Province,Nanchang 330003,China)

机构地区：[1]南昌大学第四附属医院全科医学科,江西南昌330003

出　　处：《中国当代医药》2024年第9期53-56,共4页China Modern Medicine

基　　金：江西省卫生健康委科技计划项目(202210693)。

摘　　要：目的探讨阿托伐他汀对2型糖尿病(T2DM)合并心脏自主神经病变患者氧化应激反应的影响。方法选取2021年6月至2022年12月南昌大学第四附属医院收治的80例T2DM合并DAN患者作为研究对象,按照随机数字表法分为对照组(40例)与观察组(40例)。两组均行调脂、降压、控糖等对症治疗,对照组口服二甲双胍片,基于此,观察组加用阿托伐他汀。比较两组治疗前、治疗2个月后血糖、血脂[总胆固醇(TC)、三酰甘油(TG)]以及氧化应激指标。结果两组治疗后血糖水平均低于本组治疗前,差异有统计学意义(P<0.05)。治疗后,观察组TG达(3.08±0.49)mmol/L、TC达(5.06±0.71)mmol/L均低于对照组的(3.95±0.61)mmol/L、(6.88±0.85)mmol/L,差异有统计学意义(P<0.05)。观察组治疗后丙二醛(MDA)水平低于对照组,超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)均高于对照组,差异有统计学意义(P<0.05)。结论T2DM合并DAN患者普遍存在氧化应激反应,使用阿托伐他汀进行抗氧化治疗利于缓解患者症状,减轻氧化应激反应,改善患者血脂水平,促进康复,值得临床广泛应用。Objective To investigate the effect of Atorvastatin on oxidative stress in patients with diabetes mellitus type 2(T2DM)and cardiac autonomic neuropathy.Methods A total of eighty T2DM patients with DAN admitted to the Fourth Af-filiated Hospital of Nanchang University from June 2021 to December 2022 were selected as the study objects.They were divided into a control group(40 cases)and an observation group(40 cases)by random number table method.Both groups re-ceived symptomatic treatments such as lipid-lowering,antihypertensive,and glycemic control.The control group received o-ral metformin tablets,and based on this,the observation group was additionally treated with atorvastatin.Blood glucose,blood lipids(total cholesterol[TC],triglycerides[TG]),and oxidative stress indicators between two groups before and after 2 months of treatment were compared.Results The average blood glucose levels after treatment in the two groups were lower than before treatment in the same group,and the differences were statistically significant(P<0.05).After treatment,the TG([3.08±0.49]mmol/L)and TC([5.06±0.71]mmol/L)in the observation group were lower than those in the control group([3.95±0.61]mmol/L and[6.88±0.85]mmol/L),with statistical significances(P<0.05).After treatment,the level of malondialdehyde(MDA)in the observation group was lower than that in the control group,while the levels of superoxide dismutase(SOD)and glutathione peroxidase(GSH Px)were higher than those in the control group,with statistical signifi-cances(P<0.05).Conclusion Oxidative stress reaction is common in T2DM patients with DAN.Antioxidant treatment with Atorvastatin is beneficial to alleviate oxidative stress,improve blood lipid level,and promote recovery,which is worth exten-sive clinical application.

关 键 词：2型糖尿病 心脏自主神经病变 阿托伐他汀 氧化应激 

分 类 号：R587.1[医药卫生—内分泌]