30%超分子水杨酸联合异维A酸红霉素凝胶治疗轻中度寻常痤疮的效果分析  

Effect Analysis of 30% Supramolecular Salicylic Acid Combined with Isotretinoin Erythromycin Gel in Treatment of Mild to Moderate Acne Vulgaris

作　　者：王俊秀 尹艳 庞新华 侯丽萍 Wang Junxiu;Yin Yan;Pang Xinhua;Hou Liping(Linyi Hedong District Maternal and Child Health Hospital,Linyi 276000,Shandong Province,China;Linshu County People's Hospital,Linyi 276700,Shandong Province,China)

机构地区：[1]临沂市河东区妇幼保健院,山东临沂276000 [2]临沂市临沭县人民医院,山东临沂276700

出　　处：《中国社区医师》2024年第5期35-37,共3页Chinese Community Doctors

摘　　要：目的:分析30%超分子水杨酸联合异维A酸红霉素凝胶治疗轻中度寻常痤疮的效果。方法:选取2022年1—12月临沂市河东区妇幼保健院及临沂市临沭县人民医院收治的60例轻中度寻常痤疮患者作为研究对象,按照随机数字表法分为对照组和观察组,各30例。对照组外用异维A酸红霉素凝胶治疗,观察组在对照组基础上联合30%超分子水杨酸换肤治疗。比较两组粉刺、丘疹、脓疱数量,治疗效果,不良反应发生情况。结果:治疗前,两组粉刺、丘疹、脓疱数量比较,差异无统计学意义(P>0.05);治疗后,两组粉刺、丘疹、脓疱数量少于治疗前,且观察组少于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率高于对照组,差异有统计学意义(P=0.011)。两组红斑发生率比较,差异无统计学意义(P>0.05);观察组烧灼感和干燥脱屑发生率高于对照组,差异有统计学意义(P<0.05)。结论:30%超分子水杨酸联合异维A酸红霉素凝胶治疗轻中度寻常痤疮的效果显著,可减少粉刺、丘疹、脓疱数量,但不良反应较多。Objective:To analyze the effect of 30% supramolecular salicylic acid combined with isotretinoin erythromycin gel in the treatment of mild to moderate acne vulgaris,Methods:From January 2022 to December 2022,60 patients with mild to moderate acne vulgaris admitted to Hedong District Maternal and Child Health Hospital of Linyi City and Linshu County People's Hospital of Linyi City were selected as the study subjects.They were divided into control group and observation group according to random number table method,with 30 cases in each group.The control group was treated with tropical erythromycin isotretinoin gel,and the observation group was treated with 30%supramolecular salicylic acid resurfacing on the basis of the control group.The number of acne,papules and pustules,the treatment effect and the occurrence of adverse reactions were compared between the two groups.Results:Before treatment,there was no significant difference in the number of acne,papules and pustules between the two groups(P>0.05);After treatment,the number of acne,papules and pustules in the two groups was less than that before treatment,and the number in the observation group was less than that in the control group,and the difference was statistically significant(P<0.05).The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.011).There was no significant difference in the incidence of erythema between the two groups(P>0.05);the incidence of burning sensation and dry desquamation in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:30% supramolecular salicylic acid combined with erythromycin isotretinoin gel has a significant effect in the treatment of mild to moderate acne vulgaris,and can reduce the number of acne,papules and pustules,but there are many adverse reactions.

关 键 词：痤疮 超分子水杨酸 异维A酸红霉素凝胶 安全性 

分 类 号：R751[医药卫生—皮肤病学与性病学]