孕妇外周血炎症标志物水平对胎儿侧脑室增宽的诊断价值  

Diagnostic value of maternal peripheral blood inflammatory markers on fetal lateral ventricle widening

作　　者：王芳[1] 高颖[1] 叶青[1] 崔伟[1] WANG Fang;GAO Ying;YE Qing;CUI Wei(Zhengzhou Maternal and Child Health Hospital,Zhengzhou 450000,China)

机构地区：[1]郑州市妇幼保健院,郑州450000

出　　处：《医药论坛杂志》2024年第4期369-372,378,共5页Journal of Medical Forum

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20220876)。

摘　　要：目的分析孕妇外周血炎症标志物水平对胎儿侧脑室增宽的诊断价值。方法选取郑州市妇幼保健院2021年1月至2023年8月收治的胎儿侧脑室增宽(观察组)和正常胎儿(对照组)孕妇各90例。比较两组外周血炎症标志物水平,分析炎症标志物与胎儿左/右脑室直径的相关性,以及对胎儿侧脑室增宽的预测价值和危险因素。结果观察组PLT、WBC、NLR、中性粒细胞和单核细胞计数高于对照组,淋巴细胞百分比低于对照组。WBC和中性粒细胞与胎儿左/右脑室直径均呈正相关。孕妇WBC、NLR、PLT、中性粒细胞和单核细胞计数升高是胎儿侧脑室增宽的危险因素。WBC、NLR、PLT、中性粒细胞和单核细胞计数的临界值分别为10.40×10^(9)/L、5.18、209.50×10^(9)/L、7.21×10^(9)/L和0.67×10^(9)/L,组合模型的AUC为0.704,高于任何单一变量。结论侧脑室增宽胎儿孕妇外周血炎症标志物水平与正常胎儿孕妇存在差异,WBC>10.40×10^(9)/L、NLR>5.18、PLT>209.50×10^(9)/L、中性粒细胞>7.21×10^(9)/L和单核细胞>0.67×10^(9)/L可能是胎儿侧脑室增宽的预测因素。Objective To analyze the diagnostic value of maternal peripheral blood inflammatory markers in fetal lateral ventricular widening.Methods A total of 90 pregnant women with fetal lateral ventricle enlargement(observation group)and normal fetal(control group)were selected from January 2021 to August 2023.The levels of inflammatory markers in peripheral blood were compared between the two groups,and the correlation between inflammatory markers and fetal left/right ventricle diameter was analyzed,as well as the predictive value and risk factors for fetal lateral ventri-cle widening.Results PLT,WBC,NLR,neutrophil and monocyte count in observation group were higher than control group,and lymphocyte percentage was lower than control group.WBC and neutrophils were positively correlated with fe-tal left and right ventricle diameters.Elevated WBC,NLR,PLT,neutrophil and monocyte counts in pregnant women are risk factors for fetal lateral ventricular widening.The critical values of WBC,NLR,PLT,neutrophil and monocyte count were 10.40×10^(9)/L,5.18,209.50×10^(9)/L,7.21×10^(9)/L and 0.67×10^(9)/L,respectively,and the AUC of the combined model was 0.704,higher than any single variable.Conclusion The levels of peripheral blood inflammatory markers in pregnant women with broadened lateral ventricles are different from those in pregnant women with normal fetu-ses.WBC>10.40×10^(9)/L,NLR>5.18,PLT>209.50×10^(9)/L,neutrophil>7.21×10^(9)/L and monocyte>0.67×10^(9)/L may be the predictors of fetal lateral ventricular widening.

关 键 词：胎儿侧脑室增宽 产前感染 炎症标志物 神经发育 

分 类 号：R714.43[医药卫生—妇产科学]