注射用乌司他丁联合纤维支气管镜吸痰治疗重症肺炎的疗效及对患者血清sTREM-1、sCD163的影响  

The efficacy of injectable ustekin combined with fiberoptic bronchoscopic aspiration in the treatment of severe pneumonia and the effect on soluble myeloid triggered receptor-1 and soluble CD163 molecules in patients

作　　者：王晓宇[1] 张天怡 WANG Xiaoyu;ZHANG Tianyi(Department of Emergency,Binzhou Medical College Affiliated Hospital,Binzhou 256600,China)

机构地区：[1]滨州医学院附属医院急诊科,山东滨州256600

出　　处：《黑龙江医药科学》2024年第2期86-89,共4页Heilongjiang Medicine and Pharmacy

摘　　要：目的:探究注射用乌司他丁联合纤维支气管镜吸痰治疗重症肺炎的疗效及对患者血清sTREM-1、sCD163的影响。方法:选取2020年6月至2023年6月滨州医学院附属医院收治的重症肺炎患者为研究对象。将符合排纳标准的92例重症肺炎患者随机分为对照组(n=46)和联合组(n=46)。对照组在常规治疗基础上行纤维支气管镜吸痰,联合组在对照组的基础上加用乌司他丁。观察两组患者的炎性因子水平(PCT、TNF-α、CRP)及sTREM-1、sCD163水平、血气分析指标(血氧分压和氧合指数)、临床疗效。结果:(1)治疗前,两组炎性因子水平对比(P>0.05),治疗后,联合组的炎性因子水平(TNF-α、CRP、PCT)均低于对照组(P<0.05)。(2)治疗前,两组血清sTREM-1、sCDl63水平对比(P>0.05),治疗后,联合组的血清sTREM-1、sCDl63水平均低于对照组(P<0.05)。(3)治疗前,两组血氧分压、氧合指数对比(P>0.05),治疗后,联合组的血氧分压、氧合指数均低于对照组(P<0.05)。(4)联合组的有效率为95.65%高于对照组的82.61%(P<0.05)。结论:注射用乌司他丁联合纤维支气管镜吸痰可有效改善重症肺炎患者的炎性因子水平、血气分析指标、临床疗效。Objective:to investigate the efficacy of injectable ustustekin combined with fiberoptic bronchoscopic sputum aspiration in the treatment of severe pneumonia and the effects on patients'serum sTREM-1 and sCD163.Methods:Patients with severe pneumonia admitted to the Affiliated Hospital of Binzhou Medical College from June 2020 to June 2023 were selected for the study.Ninety-two patients with severe pneumonia who met the exclusion criteria were randomly divided into the control group(n=46)and the combined group(n=46).The control group underwent fiberoptic bronchoscopic aspiration on the basis of conventional treatment,and the combined group added ustekin on the basis of the control group.Inflammatory factor levels(PCT,TNF-α,CRP)and sTREM-1,sCD163 levels,blood gas analysis indexes(partial pressure of blood oxygen and oxygenation index),and clinical efficacy were observed in the 2 groups.Results:(1)Before treatment,the levels of inflammatory factors in the 2 groups were compared(P>0.05),and after treatment,the levels of inflammatory factors(TNF-α,CRP,PCT)in the combined group were lower than those in the control group(P<0.05).(2)Before treatment,the serum sTREM-1 and sCDl63 levels of the 2 groups were compared(P>0.05),and after treatment,the serum sTREM-1 and sCDl63 levels of the combined group were lower than those of the control group(P<0.05).(3)Before treatment,the partial pressure of blood oxygen and oxygenation index of the 2 groups were compared(P>0.05),and after treatment,the partial pressure of blood oxygen and oxygenation index of the combined group were lower than that of the control group(P<0.05).(4)The effective rate of the combined group was 95.65%higher than that of the control group,which was 82.61%(P<0.05).Conclusion:Ustatin for injection combined with fiberoptic bronchoscopic aspiration can effectively improve the level of inflammatory factors,blood gas analysis indexes,and clinical efficacy of patients with severe pneumonia.

关 键 词：注射用乌司他丁 纤维支气管镜吸痰 重症肺炎 疗效 血清sTREM-1、sCD163 

分 类 号：R563.1[医药卫生—呼吸系统]