血清PCT、CRP和IL-6联合检测对细菌性血流感染的早期诊断价值  

Early Diagnostic Value of the Combined Detection of Serum PCT,CRP and IL-6 for Bacterial Bloodstream Infections

作　　者：黄蓓艳 谢翠华[1] 宗扬勇[1] HUANG Beiyan;XIE Cuihua;ZONG Yangyong(Department of Laboratory,Rugao Hospital of Traditional Chinese Medicine,Rugao,Jiangsu Province,226500 China)

机构地区：[1]如皋市中医院检验科,江苏如皋226500

出　　处：《系统医学》2024年第3期58-60,68,共4页Systems Medicine

摘　　要：目的探讨血清PCT、CRP和IL-6联合检测对细菌性血流感染早期诊断的价值。方法选取2022年6月—2023年6月如皋市中医院收治的120例疑似细菌性血流感染者为研究对象,采血检测血清降钙素原(Procal⁃citonin,PCT)、C反应蛋白(C-reactive Protein,CRP)与白细胞介素-6(Interleukin,IL-6)水平,以血培养结果为金标准,评估3项指标联合检测的诊断效能。结果120例患者的细菌感染阳性率为43.33%,阴性率为56.67%。3项指标联合检测对细菌性血流感染的诊断准确率(95.83%)和灵敏度(96.15%)高于两两指标联合检测,差异有统计学意义(P均<0.05)。3项指标联合检测的特异度(95.59%)与两两指标联合检测相比,无显著差异(P>0.05)。结论细菌性血流感染患者的PCT、CRP、IL-6水平异常升高,联合检测可提高诊断效能。Objective To investigate the value of the combined detection of serum PCT,CRP and IL-6 for the early diagnosis of bacterial bloodstream infections.Methods 120 cases of suspected bacterial bloodstream infection admit⁃ted to Rugao Hospital of Traditional Chinese Medicine from June 2022 to June 2023 were selected as the study ob⁃jects.Blood was collected to detect serum procalcitonin(PCT),C-reactive protein(CRP)and interleukin-6(IL-6)lev⁃els,and blood culture results were used as the gold standard to evaluate the diagnostic efficacy of the combined detec⁃tion of the three indicators.Results The positive rate of bacterial infection in the 120 cases was 43.33%and the nega⁃tive rate was 56.67%.The diagnostic accuracy of the three-indicator combined test for bacterial bloodstream infection was 95.83%and sensitivity 96.15%,which was higher than that of the two-two indicator combined test,and the differ⁃ences were statistically significant(all P<0.05).The specificity of the combined detection of three indicators was 95.59%,compared with the two-two indicators combined test,there was no significant difference(P>0.05).Conclu⁃sion The levels of PCT,CRP and IL-6 were abnormally elevated in patients with bacterial bloodstream infections,and the combined detection could improve the diagnostic efficacy.

关 键 词：降钙素原 C反应蛋白 白细胞介素-6 细菌性 血流感染 诊断效能 

分 类 号：R446.1[医药卫生—诊断学]