凝血功能、血小板计数、肝功能指标对不同类型肝硬化的应用价值分析  

Analysis of the Application Value of Coagulation Function,Platelet Count,and Liver Function Indexes to Different Types of Liver Cirrhosis

作　　者：李蕊 朱东来 LI Rui;ZHU Donglai(Department of Laboratory,Zhenjiang Third People's Hospital,Zhenjiang,Jiangsu Province,212000 China)

机构地区：[1]镇江市第三人民医院检验科,江苏镇江212000

出　　处：《系统医学》2024年第3期98-101,共4页Systems Medicine

摘　　要：目的分析不同类型肝硬化(乙型肝炎、酒精性及自身免疫性)的凝血参数及血小板计数指标,并对不同病因导致的肝硬化其凝血指标差异的意义进行探析。方法回顾性分析2021年1月—2023年1月镇江市第三人民医院检验科收治的90例肝硬化患者的临床资料,以患者病因为依据,将收治的肝硬化患者分为乙型肝炎组、酒精性肝硬化组、自身免疫性肝硬化组,每组30例,对比3组患者的凝血参数、肝功能指标及血小板指数。结果乙型肝炎肝硬化组、酒精性肝硬化组的凝血酶原时间(Prothrombin Time,PT)、国际标准化比值(International Normalized Ratio,INR)、活化部分凝血活酶时间(Activated Partial Thromboplastin Time,APTT)、凝血酶时间(Thrombin Time,TT)水平均高于自身免疫性肝硬化组,纤维蛋白原(Fibrinogen,FIB)水平低于自身免疫性肝硬化组,差异有统计学意义(P均<0.05);酒精性肝硬化组、乙型肝炎肝硬化组的丙氨酸氨基转移酶(Alanine Aminotransferase,ALT)、天冬氨酸氨基转移酶(Aspartate Aminotransferase,AST)水平均低于自身免疫性肝硬化组,差异有统计学意义(P均<0.05);乙型肝炎肝硬化组、酒精性肝硬化组的血小板计数(Platelet Count,PLT)、血小板压积(Plateletcrit,PCT)水平均低于自身免疫性肝硬化组,差异有统计学意义(P均<0.05)。结论在凝血功能、血小板计数、肝功能指标方面,不同类型肝硬化(乙型肝炎、酒精性、自身免疫性)患者均存在差异性,临床可用其对肝硬化类型进行诊断。Objective To analyze the coagulation parameters and platelet count indexes of different types of cirrhosis(hepatitis B,alcoholic and autoimmune),and to explore the significance of the differences in coagulation indexes of cir⁃rhosis caused by different etiologies.Methods The clinical data of 90 patients with cirrhosis admitted to the clinical Department of Zhenjiang Third People's Hospital from January 2021 to January 2023 were retrospectively analyzed.According to the disease cause,the patients with cirrhosis were divided into hepatitis B group,alcoholic cirrhosis group and autoimmune cirrhosis group,with 30 cases in each group.The coagulation parameters,liver function in⁃dexes and platelet indexes of the 3 groups were compared.Results The levels of prothrombin time(PT),international standardized ratio(INR),activated partial thromboplastin time(APTT),and thrombin time(TT)in patients with hepati⁃tis B group and alcoholic cirrhosis group were higher than those with autoimmune cirrhosis group,and the differences were statistically significant(all P<0.05).The levels of fibrinogen(FIB)in patients with hepatitis B group and alco⁃holic cirrhosis group were lower than those with autoimmune cirrhosis group,and the difference was statistically sig⁃nificant(P<0.05).The levels of alanine aminotransferase(ALT)and aspartate aminotransferase(AST)in alcoholic cirrhosis group and hepatitis B cirrhosis group were lower than those in autoimmune cirrhosis group,and the differences were statistically significant(all P<0.05).The levels of platelet count(PLT)and plateletcrit(PCT)in the hepatitis B cirrhosis group and alcoholic cirrhosis group were lower than those in the autoimmune cirrhosis group,and the differ⁃ences were statistically significant(all P<0.05).Conclusion In terms of coagulation function,platelet count and liver function indexes,different types of cirrhosis(hepatitis B,alcoholic,autoimmune)patients have differences,which can be used by clinics to diagnose the type of cirrhosis.

关 键 词：乙型肝炎肝硬化 酒精性肝硬化 自身免疫性肝硬化 凝血参数 

分 类 号：R44[医药卫生—诊断学]