蓝光照射联合果糖二磷酸钠治疗新生儿重度高胆红素血症的安全性  

Safety of Blue Light Irradiation Combined with Sodium Fructose Diphosphate in the Treatment of Neonatal Severe Hyperbilirubinemia

作　　者：刘艳春 LIU Yanchun(Department of Pediatrics,Jining Third People's Hospital(Yanzhou District People's Hospital),Jining,Shandong Province,272000 China)

机构地区：[1]济宁市第三人民医院(济宁市兖州区人民医院)儿科,山东济宁272000

出　　处：《系统医学》2024年第3期154-156,160,共4页Systems Medicine

摘　　要：目的探究传统蓝光照射联合果糖二磷酸钠治疗新生儿重度高胆红素血症安全性。方法选取2020年3月—2023年3月济宁市第三人民医院收治的102例重度高胆红素血症新生儿作为研究对象,通过随机数表法分为分析组(n=51,传统蓝光照射+果糖二磷酸钠治疗)和对照组(n=51,传统蓝光照射治疗)。比较两组的症状改善时间、胆红素水平、神经功能以及安全性。结果分析组皮肤黄染消失时间(5.31±1.05)d较对照组(6.33±1.10)d短,差异有统计学意义(t=4.790,P<0.05)。治疗前,两组胆红素水平、神经功能对比,差异无统计学意义(P均>0.05);治疗后,两组胆红素水平、神经功能显著改善,且分析组改善程度明显好于对照组,差异有统计学意义(P均<0.05)。分析组不良反应总发生率(1.96%)显著低于对照组(29.41%),差异有统计学意义(P<0.05)。结论给予重度高胆红素血症新生儿传统蓝光照射联合果糖二磷酸钠治疗,可有效缩短症状改善时间,显著改善患儿的胆红素水平、神经功能,且安全性更高。Objective To explore the safety of traditional blue light irradiation combined with sodium fructose diphos⁃phate in the treatment of severe hyperbilirubinemia in neonates.Methods A total of 102 neonates with severe hyper⁃bilirubinemia were admitted to Jining Third People's Hospital from March 2020 to March 2023 were selected as the study objects.The patients were divided into analysis group(n=51,traditional blue light irradiation+fructose diphos⁃phate treatment)and control group(n=51,traditional blue light irradiation treatment)by random number table method.Symptom improvement time,bilirubin levels,neurological function,and safety were compared between the two groups.Results Disappearance time of skin stained yellow time in analysis group(5.31±1.05)d was significantly shorter than that in control group(6.33±1.10)d,and the difference was statistically significant(t=4.790,P<0.05).Before treatment,there were no significant differences in bilirubin level and nerve function between the two groups(both P>0.05).After treatment,the bilirubin level and nerve function of the two groups were significantly improved,and the improvement degree of the analysis group was significantly better than that of the control group,the differences were statistically sig⁃nificant(all P<0.05).The total incidence of adverse reactions in the analysis group(1.96%)was significantly lower than that in the control group(24.41%),and the difference was statistically significant(P<0.05).Conclusion Tradi⁃tional blue light irradiation combined with sodium fructose diphosphate treatment in neonates with severe hyperbiliru⁃binemia can effectively shorten the time of symptom improvement,significantly improve the level of bilirubin and neu⁃rological function of the children,and is safer.

关 键 词：蓝光照射 新生儿 重度高胆红素血症 安全性 

分 类 号：R722[医药卫生—儿科]