艾滋病合并结核相关免疫重建炎症反应综合征的研究进展  

Research progress of AIDS combined with tuberculosis-associated immune reconstitution inflammatory response syndrome

作　　者：何景冬 梁跃东 龙海 何娟 涂文瑶 HE Jingdong;LIANG Yuedong;LONG Hai;HE Juan;TU Wenyao(Department of Infection,Affiliated Hospital of Guizhou Medical University,Guiyang,Guizhou 550000,China;Department of Infection,Guiyang Public Health and Treatment Center,Guiyang,Guizhou 550000,China)

机构地区：[1]贵州医科大学附属医院感染科,贵州贵阳550000 [2]贵阳市公共卫生救治中心感染科,贵州贵阳550000

出　　处：《安徽医药》2024年第5期854-859,共6页Anhui Medical and Pharmaceutical Journal

基　　金：贵州省科技计划项目(黔科合支撑〔2021〕一般055)。

摘　　要：20世纪80年代以来,艾滋病(AIDS)在全球范围内蔓延,严重危害人类健康。结核病(TB)是艾滋病病人常见的一种机会性感染,同时也是导致病人死亡的重要原因之一。当病人同时感染人类免疫缺陷病毒(HIV)及结核分枝杆菌(MTB),两者可相互促进,使艾滋病病人病情变得更加复杂,并最终可能发展为艾滋病(AIDS)合并结核相关免疫重建炎症反应综合征(TB-IRIS)。目前针对这类疾病的研究不多,主要依赖临床医师的经验进行诊断和治疗。该文对AIDS合并TB-IRIS的发病机制及其疾病发生进展的关系进行分析,探讨如何更好地防治并发症,以期为临床诊断、治疗和研究提供参考性意见。Since the 1980s,acquired immunodeficiency syndrome(AIDS)has spread around the world,seriously endangering human health.Tuberculosis(TB)is a common opportunistic infection in AIDS patients,and it is also one of the important causes of death.When patients are co-infected with human immunodeficiency virus(HIV)and Mycobacterium tuberculosis(MTB),the two can promote each other,making the condition of AIDS patients more complicated,and eventually may develop into AIDS with tuberculosis associat⁃ed immune reconstitution inflammatory response syndrome(TB-IRIS).At present,there are few studies on this kind of disease,which mainly rely on the experience of clinicians for diagnosis and treatment.Therefore,the article analyzes the pathogenesis of AIDS compli⁃cated with TB-IRIS and its relationship with disease progression,and discusses how to better prevent and treat complications,in order to provide reference for clinical diagnosis,treatment and research.

关 键 词：获得性免疫缺陷综合征 艾滋病相关机会致病菌感染 结核病 免疫重建 诊治 

分 类 号：R512.91[医药卫生—内科学] R52[医药卫生—临床医学]