长链的非编码RNA生长停滞特异性转录本5在骨关节炎中的研究进展  

Research progress of LncRNA GAS5 in osteoarthritis

作　　者：张晓彤 郝婧婧 李芳[2] 纪斌平 张芳芳 ZHANG Xiaotong;HAO Jingjing;LI Fang;JI Binping;ZHANG Fangfang(Second Clinical Medical College of Shanxi Medical University,Taiyuan,Shanxi 030000,China;Department of Rheumatology and Immunology,The Second Hospital of Shanxi Medical Universi-ty,Taiyuan,Shanxi 030000,China;Department of Orthopaedics,Shanxi Huajin Orthopaedic Hospital,Taiyuan,Shanxi 030400,China)

机构地区：[1]山西医科大学第二临床医学院,山西太原030000 [2]山西医科大学第二医院风湿免疫科,山西太原030000 [3]山西华晋骨科医院骨科,山西太原030400

出　　处：《安徽医药》2024年第5期870-873,共4页Anhui Medical and Pharmaceutical Journal

基　　金：山西省归国留学人员科研基金(晋财社〔2018〕123号);山西省华晋骨科公益基金(20210401)。

摘　　要：骨关节炎(OA)是一种以软骨退变、骨重建为主要病理特点的慢性关节疾病。目前没有可治愈该疾病的药物及手段,治疗策略有限的根本原因是对其潜在发病机制的认识不足。长链的非编码RNA(LncRNAs)被认为是许多疾病中的一类新的调控因子,是目前研究OA发病机制的一个重要切入点。LncRNA生长停滞特异性转录本5(Cas5)参与调控细胞的增殖、分化及凋亡,是一种在软骨细胞中特异性高表达的LncRNA。然而,由于LncRNA Cas5作用机制复杂,其与OA相关具体分子机制目前仍不明确。该文针对LncRNA Cas5在OA中的软骨细胞凋亡、软骨基质代谢成骨分化及治疗方面的作用进行综述。Osteoarthritis(OA)is a chronic joint disease with cartilage degeneration and bone reconstruction as its main pathologic fea⁃tures.At present,there are no drugs and means to cure the disease,and the primary cause of the limited treatment strategies is the in⁃sufficient understanding of the underlying pathogenesis.Long non-coding RNAs(LncRNAs)are considered as a new class of regulators for many diseases and an important point for studying the pathogenesis of OA.LncRNA growth arrest specific transcript 5(GAS5)is in⁃volved in the regulation of cell proliferation,differentiation and apoptosis,and is an LncRNA specifically and highly expressed in chon⁃drocytes.However,due to the complex mechanism of LncRNA GAS5,the specific molecular mechanism associated with osteoarthritis is still unclear.This review addressed the role of LncRNA GAS5 in chondrocyte apoptosis,the metabolism and osteogenic differentia⁃tion of cartilage matrix,and its treatment.

关 键 词：骨关节炎 长链非编码RNA 生长停滞特异性转录本5 

分 类 号：R684.3[医药卫生—骨科学]