宁波市COVID-19 Delta变异株既往感染者复检阳性人员流行特征  

Epidemiological characteristics analysis of re-positive patients infected with COVID-19 Delta variant strains

作　　者：王思嘉 张栋梁[2] 易波[2] 陈奕[2] 褚衍茹 闫克栋 李巧方 雷松 张言武 许国章 WANG Sijia;ZHANG Dongliang;YI Bo;CHEN Yi;CHU Yanru;YAN Kedong;LI Qiaofang;LEI Song;ZHANG Yanwu;XU Guozhang(Institute for Chronic and Non-Communicable Disease Control and Prevention,Ningbo Center for Disease Control and Prevention,Ningbo 315010,China;Institute for Communicable Disease Control and Prevention,Ningbo Center for Disease Control and Prevention,Ningbo 315010,China;Zhejiang Province Field Epidemiology Training Program,Hangzhou 310051,China;Institute for Communicable Disease Control and Prevention,Beilun District Center for Disease Control and Prevention,Ningbo 315800,China;Ningbo University Medical Science Center,Ningbo 315200,China)

机构地区：[1]宁波市疾病预防控制中心慢性非传染性疾病防制所,宁波315010 [2]宁波市疾病预防控制中心传染病防制所,宁波315010 [3]浙江省现场流行病学培训项目,杭州310051 [4]宁波市北仑区疾病预防控制中心传染病防制所,宁波315800 [5]宁波大学医学部,宁波315200

出　　处：《中华疾病控制杂志》2024年第3期335-338,344,共5页Chinese Journal of Disease Control & Prevention

基　　金：宁波市应急科技攻关重大专项(2022Z034)。

摘　　要：目的分析宁波市2起Delta变异株引起的COVID-19疫情中感染者出院后核酸检测再次阳性(复阳)的流行特征,为感染者出院后管理提供科学依据。方法收集宁波市2021年12月6日―2022年5月31日2起COVID-19疫情中复阳人员的流行病学相关信息及临床信息。分析其流行病学特征、临床表现、传染性及影响因素。结果共纳入112例COVID-19者,其中复阳65例,复阳率为58.04%。性别、年龄、职业、疫苗接种、临床严重程度、Delta毒株基因型别均对既往感染者复阳无影响(均P>0.05)。复阳人员入院后中位住院时长为5.00(3.25,8.75)d,短于首次发病确诊后的中位住院时长25.00(22.00,31.50)d(U=-6.724,P<0.001)。复阳人员均表现为无症状,其临床严重程度轻于首次发病确诊后(χ^(2)=1.888,P<0.001)。复阳人员的密切接触者感染率低于病例首次确诊后的感染率,但差异无统计学意义(0.00%∶1.67%,P=0.262)。结论新型冠状病毒(新冠病毒)Delta变异株既往感染者复阳后无临床症状,无传染性,建议在排除二次感染的前提下半年内不再进行核酸检测和隔离管控。Objective To analyze the epidemiological characteristics of the re-positive patients in two COVID-19 outbreaks caused by Delta variant strains in Ningbo,to provide a scientific basis for better management.Methods The epidemiological and clinical information of the re-positive patients in two COVID-19 outbreaks in Ningbo from December 6,2021,to May 31,2022,were collected.The epidemiological characteristics,clinical manifestations,infectivity,and influencing factors were analyzed.Results A total of 112 patients with COVID-19 infection were included in this study,of which 65 were re-positive,the re-positive rate was 58.04%.Gender,age,occupation,vaccination,clinical severity,and genotype of delta strain did not affect the re-positive of previously infected patients(all P>0.05).The median hospital stay of re-positive was 5.00(3.25,8.75)days,which was shorter than the median stay of 25.00(22.00,31.50)days after the first diagnosis(U=-6.724,P<0.001).All the re-positive persons were asymptomatic,and their clinical severity was lighter than that after the first diagnosis(χ^(2)=1.888,P7lt;0.001).The infection rate of close contacts of the re-positive persons was lower than the infection rate after the case was first diagnosis(0.00%∶1.67%,P=0.262),but the difference was not statistically significant.Conclusion s Re-positive persons with previous infections of the COVID-19 Delta variant had no clinical symptoms and no infectivity.It is recommended that nucleic acid testing and isolation should not be carried out within the second half of the year after excluding secondary infection.

关 键 词：新型冠状病毒感染 DELTA 复阳 传染性 

分 类 号：R211[医药卫生—中医学] R51