病毒宏基因组学在蜱媒病毒研究中的应用进展  

Application progress of virus metagenomics in study of tick-borne virus

作　　者：孙世伟 陆振华 龙泳 邵中军 SUN Shiwei;LU Zhenhua;LONG Yong;SHAO Zhongjun(Department of Epidemiology,Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment,School of Public Health,The Air Force Medical University,Xi′an 710032,China;School of Public Health,Baotou Medical College,Baotou 014000,China)

机构地区：[1]空军医科大学公共卫生学院特殊作业环境危害评价与控制教育部重点实验室流行病学教研室,西安710032 [2]包头医学院公共卫生学院,包头014000

出　　处：《中华疾病控制杂志》2024年第3期357-360,共4页Chinese Journal of Disease Control & Prevention

基　　金：国家自然科学基金(82273689);军队后勤科研计划重点项目(BWS20J020);军队医学科技青年培育计划拔尖项目(21QNPY087)。

摘　　要：蜱是广泛分布于全球的专性吸血体外寄生虫,是世界上最主要的病媒生物之一,携带的病原体涵盖了细菌、病毒、螺旋体等。其中以蜱媒病毒为主要的虫媒病毒之一,给人类和动物的健康带来了极大的威胁。病毒宏基因组学是近年来基于宏基因组学兴起的病毒研究技术,它的出现为研究已知和未知病毒及其多样性提供了有力支持,给病毒研究带来了全新的技术手段和思路。本文综述了病毒宏基因组学在蜱媒病毒研究中的进展,以期为蜱媒病毒研究提供参考依据。Ticks are specific blood-sucking ectoparasites which are widely distributed all over the world.They are one of the most important vector organism in the world,carrying pathogens including bacteria,viruses,spirochetes etc.Among them,tick-borne virus is the major arbovirus,which brings great burden to human and animal health.Virus metagenomics have been a virus research technology based on metagenomics in recent years.Its emergence provides strong support for the study of known and unknown viruses and their diversity,and brings new technical means and ideas to virus research.This paper reviews the research progress of viral metagenomics in tick-borne virus research to provide useful reference for tick-borne virus research.

关 键 词：蜱 蜱媒病毒 宏基因组学 高通量测序 

分 类 号：R373[医药卫生—病原生物学] R181[医药卫生—基础医学]