The Versatility and Diagnostic Potential of VOC Profiling for Noninfectious Diseases  

作　　者：Micah Oxner Allyson Trang Jhalak Mehta Christopher Forsyth Barbara Swanson Ali Keshavarzian Abhinav Bhushan 

机构地区：[1]Department of Biomedical Engineering,Illinois Institute of Technology,Chicago,IL 60616,USA [2]Department of Internal Medicine,Division of Digestive Diseases and Nutrition,Section of Gastroenterology,Rush Medical College,Chicago,IL 60612,USA [3]Department of Adult Health and Gerontological Nursing,Rush University College of Nursing,Chicago,IL 60612,USA

出　　处：《Biomedical Engineering Frontiers》2023年第1期274-297,共24页生物医学工程前沿（英文）

基　　金：This work was partly supported by funds from the National Science Foundation,Award Number 2031762(A.B.)and 2031754(A.K.)。

摘　　要：variety of volatile organic compounds(VOCs)are produced and emitted by the human body every day.The identity and concentration of these VOCs reflect an individual’s metabolic condition.Information regarding the production and origin of VOCs,however,has yet to be congruent among the scientific community.This review article focuses on the recent investigations of the source and detection of biological VOCs as a potential for noninvasive discrimination between healthy and diseased individuals.Analyzing the changes in the components of VOC profiles could provide information regarding the molecular mechanisms behind disease as well as presenting new approaches for personalized screening and diagnosis.VOC research has prioritized the study of cancer,resulting in many research articles and reviews being written on the topic.This review summarizes the information gained about VOC cancer studies over the past 10 years and looks at how this knowledge correlates with and can be expanded to new and upcoming fields of VOC research,including neurodegenerative and other noninfectious diseases.Recent advances in analytical techniques have allowed for the analysis of VOCs measured in breath,urine,blood,feces,and skin.New diagnostic approaches founded on sensor-based techniques allow for cheaper and quicker results,and we compare their diagnostic dependability with gas chromatography-and mass spectrometry-based techniques.The future of VOC analysis as a clinical practice and the challenges associated with this transition are also discussed and future research priorities are summarized.

关 键 词：VOC gained summarized 

分 类 号：R318[医药卫生—生物医学工程]