氟苯尼考在泰和乌鸡可食性组织中残留消除规律研究  

Residue Depletion of Florfenicol in Various Edible Tissues of Taihe Black-bone Silky Fowl

作　　者：龙伟 肖娜 袁丽娟[1] 向建军 张莉[1] 张大文[1] 廖且根[1] 陈宏晖 LONG Wei;XIAO Na;YUAN Lijuan;XIANG Jianjun;ZHANG Li;ZHANG Dawen;LIAO Qiegen;CHEN Honghui(Key Laboratory for Quality and Safety Control of Poultry Products,Ministry of Agriculture and Rural Affairs,Institute for Quality&Safety and Standards of Agricultural Products Research,Jiangxi Academy of Agricultural Sciences,Nanchang,Jiangxi 330200;Ji'an Agricultural Products Quality and Safety Testing Center,Ji'an,Jiangxi 343001;Ji'an Vocational and Technical College of Modern Agriculture and Forestry,Ji'an,Jiangxi 343001;Ji'an Agricultural and Rural Industry Development Service Center,Ji'an,Jiangxi 343001)

机构地区：[1]江西省农业科学院农产品质量安全与标准研究所,农业农村部禽类产品质量安全控制重点实验室,江西南昌330200 [2]吉安市农产品质量安全检测中心,江西吉安343001 [3]吉安职业技术学院现代农林工程学院,江西吉安343001 [4]吉安市农业农村产业发展服务中心,江西吉安343001

出　　处：《中国家禽》2024年第4期80-87,共8页China Poultry

基　　金：江西省农业科学院基础研究与人才培养专项(JXSNKYJCRC202201);江西省主要学科学术和技术带头人培养计划—领军人才项目(20213BCJ22008);吉安市科技计划项目(20211-025390)。

摘　　要：为研究氟苯尼考可溶性粉在泰和乌鸡体内可食性组织的残留变化规律,试验选择64只110日龄健康泰和乌鸡(公母各半),按推荐剂量0.5 g可溶性氟苯尼考粉/L饮用水连续给药5 d。在停药后第0.16、1、3、5、7、9、12、15天随机屠宰4只公鸡和4只母鸡,分别采集肌肉、肝脏、肾脏、皮脂样本,采用超高效液相色谱-串联质谱联用法测定组织中氟苯尼考和氟苯尼考胺残留量,并利用WT1.4软件计算氟苯尼考在泰和乌鸡体内的休药期。结果显示,氟苯尼考和氟苯尼考胺在泰和乌鸡肌肉、肝脏、肾脏组织内残留消除较为迅速,而在皮脂组织消除相对缓慢;氟苯尼考可溶性粉在泰和乌鸡肌肉、肝脏、肾脏、皮脂中的休药时间分别为4.36 d、0.00 d、0.00 d、9.81 d。研究表明,为保证泰和乌鸡产品质量安全,氟苯尼考在泰和乌鸡体内的推荐休药期应大于10 d。To study the residue depletion of florfenicol in various tissues of Taihe black-bone silky fowl were examined(half male and half female),64 healthy 110-day-age Taihe black-bone silky fowls were given 0.5 g florfenicol soluble powder per liter drinking water continuously for 5 days.Four cocks and four hens were selected randomly to slaughter at 0.16,1,3,5,7,9,12 and 15 days after drug withdrawal,and muscle,liver,kidney and sebum samples were collected from each chicken,respectively.The residues of florfenicol and florfenicol amine in tissue samples were determined by ultra-performance liquid chromatography-tan⁃dem mass spectrometry,and the withdrawal period of florfenicol in Taihe black-bone silky fowl was calculated by WT1.4 soft⁃ware.The results showed that florfenicol and florfenicol amine were eliminated rapidly in muscle,liver and kidney tissues of Tai⁃he black-bone silky fowl,but eliminated relatively slowly in sebum tissues.The withdrawal time in muscle,liver,kidney and se⁃bum was 4.36,0.00,0.00,9.81 days,respectively.It's indicated that the recommended withdrawal period of forfenicol in Taihe black-bone silky fowl should be more than 10 days to ensure the quality and safety of products.

关 键 词：氟苯尼考 氟苯尼考胺 泰和乌鸡 休药期 

分 类 号：S859.84[农业科学—临床兽医学]