MRI联合血清TSGF、NDRG4在上皮性卵巢癌诊断中的作用  

The Role of MRI Combined with Serum TSGF and NDRG4 in The Diagnosis of Epithelial Ovarian Cancer

作　　者：柯楠 刘凯 陈娇 汪晶 Ke Nan;Liu Kai;Chen Jiao;Wang Jing(Medical Imaging Department of Huanggang Central Hospital of Yangtze University,Huanggang 438000,Hubei Province,China;Department of Geriatrics,Huanggang Central Hospital of Yangtze University,Huanggang 438000,Hubei Province,China;Department of Gynecology,Renmin Hospital of Wuhan University,Wuhan 430060,Hubei Province,China)

机构地区：[1]长江大学附属黄冈市中心医院医学影像科,湖北黄冈438000 [2]长江大学附属黄冈市中心医院老年医学科,湖北黄冈438000 [3]武汉大学人民医院妇科,湖北武汉430060

出　　处：《中国CT和MRI杂志》2024年第4期119-121,共3页Chinese Journal of CT and MRI

基　　金：湖北省自然科学基金(WJ2019A265)。

摘　　要：目的探讨血清肿瘤特异性生长因子(TSGF)、N-Myc下游调节基因4(NDRG4)在上皮性卵巢癌血清中的表达以及联合磁共振成像(MRI)在上皮性卵巢癌诊断中的作用。方法收集本院2021年1月~2022年8月期间进行手术的60例上皮性卵巢癌患者(卵巢癌组)作为研究对象,同时选取与上皮性卵巢癌患者临床资料一致的妇科良性肿瘤患者(良性组)和健康体检者(对照组)各60例。比较各组血清TSGF、NDRG4水平;ROC曲线分析血清TSGF、NDRG4分别对上皮性卵巢癌的诊断效能;四表格法分析MRI联合血清TSGF、NDRG4对上皮性卵巢癌的诊断效能。结果卵巢癌组血清TSGF水平显著高于良性组和对照组(P<0.05),血清NDRG4水平显著低于良性组和对照组(P<0.05);良性组血清TSGF水平显著高于对照组(P<0.05),血清NDRG4水平显著低于对照组(P<0.05)。MRI联合血清TSGF、NDRG4诊断上皮性卵巢癌的准确率为93.33%,敏感性为95.00%,特异性为91.67%。其中,三项联合诊断的特异性高于NDRG4、MRI单独诊断(P<0.05),三项联合诊断的准确率和敏感性高于TSGF、NDRG4单独诊断(P<0.05)。结论上皮性卵巢癌患者血清TSGF的表达水平显著升高,NDRG4的表达水平显著降低,MRI联合血清TSGF、NDRG4对上皮性卵巢癌具有一定的诊断价值。Objective To investigate the expression of tumor specific growth factor(TSGF)and N-Myc downstream regulator gene 4(NDRG4)in serum of epithelial ovarian cancer and the role of combined magnetic resonance imaging(MRI)in the diagnosis of epithelial ovarian cancer.Methods Sixty patients with epithelial ovarian cancer(ovarian cancer group)who underwent surgery in our hospital from January 2021 to August 2022 were collected as research subjects,meantime,60 patients with gynecological benign tumor(benign group)and 60 healthy people(control group)were selected,which were consistent with the clinical data of patients with epithelial ovarian cancer.The levels of serum TSGF and NDRG4 in each group were compared;receiver operating characteristic was applied to analyze the diagnostic efficacy of serum TSGF and NDRG4 for epithelial ovarian cancer;four grid table method were applied to analyze the diagnostic efficacy of MRI combined with serum TSGF and NDRG4 in epithelial ovarian cancer.Results The serum TSGF level in the ovarian cancer group was obviously higher than that in the benign and control groups(P<0.05),and the serum NDRG4 level was obviously lower than that in the benign and control groups(P<0.05);the serum TSGF level in the benign group was obviously higher than that in the control group(P<0.05),while the serum NDRG4 level was obviously lower than that in the control group(P<0.05).The accuracy,sensitivity,and specificity of MRI combined with serum TSGF and NDRG4 in diagnosing epithelial ovarian cancer were 93.33%,95.00%,and 91.67%,respectively.Among them,the specificity of the three combined diagnoses was higher than that of NDRG4 and MRI alone(P<0.05),and the accuracy and sensitivity of the three combined diagnoses were higher than those of TSGF and NDRG4 alone(P<0.05).Conclusion The expression level of serum TSGF is obviously increased in patients with epithelial ovarian cancer,while the expression level of NDRG4 is obviously reduced.MRI combined with serum TSGF and NDRG4 has certain diagnostic value for epithelia

关 键 词：磁共振成像 肿瘤特异性生长因子 N-Myc下游调节基因4 上皮性卵巢癌 诊断 

分 类 号：R445.2[医药卫生—影像医学与核医学] R44[医药卫生—诊断学]