丙硫氧嘧啶和甲巯咪唑治疗甲亢的效果对比  

Comparison of the Effects of Propylthiouracil and Thiamazole in the Treatment of Hyperthyroidism

作　　者：刘国军 LIU Guojun(Guizhou Panjiang Coal and Electricity Group Co.,Ltd.Hospital,Panzhou 553536,China)

机构地区：[1]贵州盘江煤电集团有限责任公司医院,贵州盘州553536

出　　处：《中外医学研究》2024年第5期56-59,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:分析比较丙硫氧嘧啶、甲巯咪唑治疗甲亢患者的效果。方法:选择2021年4月—2023年6月贵州盘江煤电集团有限责任公司医院收治的100例甲亢患者,随机分为两组,各50例。对照组采用丙硫氧嘧啶治疗,试验组采用甲巯咪唑治疗。比较两组的治疗效果、甲状腺功能指标、肝功能指标及不良反应发生情况。结果:治疗后,试验组治疗总有效率明显高于对照组,差异有统计学意义(P<0.05)。治疗前,两组甲状腺功能指标比较,差异无统计学意义(P>0.05);治疗后,两组游离三碘甲腺原氨酸(FT_(3))、游离四碘甲腺原氨酸(FT_(4))低于治疗前,促甲状腺激素(TSH)高于治疗前,且试验组FT_(3)、FT_(4)低于对照组,TSH高于对照组,差异有统计学意义(P<0.05)。治疗前,两组肝功能指标比较,差异无统计学意义(P>0.05);治疗后,两组总胆红素(TBIL)、碱性磷酸酶(ALP)、丙氨酸转氨酶(ALT)高于治疗前,但试验组均低于对照组,差异有统计学意义(P<0.05)。试验组不良反应总发生率明显低于对照组,差异有统计学意义(P<0.05)。结论:甲亢患者采用甲巯咪唑进行治疗获得了显著效果,能够有效改善患者甲状腺功能,对机体肝脏的损伤更小,且不良反应率更低,相比于丙硫氧嘧啶更加安全有效。Objective:To analyze and compare the efficacy of Propylthiouracil and Thiamazole in the treatment of hyperthyroidism.Method:A total of 100 hyperthyroidism patients admitted to Guizhou Panjiang Coal and Electricity Group Co.,Ltd.Hospital from April 2021 to June 2023 were randomly divided into two groups,with 50 cases in each group.The control group was treated with Propylthiouracil and the experimental group was treated with Thiamazole.The therapeutic effect,thyroid function index,liver function index and the occurrence of adverse reactions were compared between the two groups.Result:After treatment,the total effective rate of experimental group was significantly higher than that of control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in thyroid function indexes between the two groups(P>0.05).After treatment,free triiodothyronine(FT_(3))and free tetraiodothyronine(FT_(4))in two groups were lower than those before treatment,and thyroid stimulating hormone(TSH)were higher than those before treatment,and FT_(3) and FT_(4) in experimental group were lower than those in control group,and TSH was higher than that in control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in liver function indexes between the two groups(P>0.05).After treatment,total bilirubin(TBIL),alkaline phosphatase(ALP)and alanine aminotransferase(ALT)in two groups were higher than those before treatment,but those in the experimental group were lower than those in the control group,the differences were statistically significant(P<0.05).The total incidence of adverse reactions in experimental group was significantly lower than that in control group,and the difference was statistically significant(P<0.05).Conclusion:The treatment of hyperthyroidism with Thiamazole has achieved remarkable results,which can effectively improve the thyroid function of patients with less damage to the liver and lower adverse reaction

关 键 词：丙硫氧嘧啶 甲巯咪唑 甲亢 效果 不良反应 甲状腺功能 肝功能 

分 类 号：R581.1[医药卫生—内分泌]