骨痛灵酊联合美洛昔康片治疗对膝骨关节炎患者预后的影响  

Effect of Gutongling Tincture Combined with Meloxicam Tablets on the Prognosis of Patients with Knee Osteoarthritis

作　　者：王发玉 WANG Fayu(Linyi County Traditional Chinese Medicine Hospital Linpan Campus,Linyi 251500,China)

机构地区：[1]临邑县中医院临盘院区,山东临邑251500

出　　处：《中外医学研究》2024年第6期38-42,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨骨痛灵酊联合美洛昔康片治疗对膝骨关节炎患者预后的影响。方法:回顾性选取2020年2月—2023年2月临邑县中医院临盘院区收治的100例膝骨关节炎患者,依据用药方法分为联合治疗组、单独治疗组,各50例。联合治疗组给予骨痛灵酊联合美洛昔康片治疗,单独治疗组给予单独美洛昔康片治疗。统计分析两组中医症候积分、疼痛程度、膝关节功能、步态功能、健康状况、生活质量、骨代谢指标、氧化应激指标、炎症因子、临床疗效。结果:治疗后,联合治疗组各项中医症候积分及总分、西安大略和麦克马斯特大学(WOMAC)骨关节炎指数各项评分及总分、奎森运动功能指数(Lequesne评分)、视觉模拟评分法(VAS)评分、健康评价调查表(HAQ)评分、丙二醛(MDA)、一氧化氮(NO)、肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、白细胞介素-17(IL-17)均低于单独治疗组,6分钟步行试验(6MWT)距离长于单独治疗组,Berg平衡量表(BBS)评分、生活质量评价简表(SF-36)评分、骨钙素(BGP)、骨保护素(OPG)、谷胱甘肽(GSH)、超氧化物歧化酶(SOD)均高于单独治疗组,差异有统计学意义(P<0.05)。联合治疗组治疗总有效率为96.00%,高于单独治疗组的78.00%,差异有统计学意义(P<0.05)。结论:膝骨关节炎患者采用骨痛灵酊联合美洛昔康片治疗效果更好,可缓解疼痛,改善膝关节功能、步态功能,提高生活质量、优化健康状况,调节骨代谢指标、氧化应激指标及炎症因子。Objective:To investigate the effect of Gutongling Tincture combined with Meloxicam Tablets on the prognosis of patients with knee osteoarthritis.Method:Retrospective selection of 100 patients with knee osteoarthritis admitted to the Linyi County Traditional Chinese Medicine Hospital Linpan Campus from February 2020 to February 2023.According to medication methods,they were divided into combination treatment group and single treatment group,with 50 patients in each group.The combination treatment group was treated with Gutongling Tincture combined with Meloxicam Tablets,while the single treatment group was treated with Meloxicam Tablets.Statistical analysis of two groups of traditional Chinese medicine syndrome scores,pain severity,knee joint function,gait function,health status,quality of life,bone metabolism indicators,oxidative stress indicators,inflammatory factors,and clinical efficacy.Result:After treatment,various traditional Chinese medicine symptom scores and total scores,the Western Ontario and McMaster University(WOMAC)osteoarthritis index scores and total scores,Lequesne score,visual analogue scale(VAS)score,health assessment questionnaire(HAQ)score,malondialdehyde(MDA),nitric oxide(NO),tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),interleukin-6(IL-6)and interleukin-17(IL-17)in the combination treatment group were lower than those in the single treatment group,the 6 min walking test(6MWT)distance was longer than that of the single treatment group,the Berg balance scale(BBS)score,the MOS item short from health survey(SF-36)score,bone glutamyl protein(BGP),osteoprotegerin(OPG),glutathione(GSH),and superoxide dismutase(SOD)levels were all higher than those in the single treatment group,and the differences were statistically significant(P<0.05).The total effective rate of the combination treatment group was 96.00%,which was higher than 78.00% of the single treatment group,and the difference was statistically significant(P<0.05).Conclusion:The combination of Gutongling Tincture and Meloxicam Tabl

关 键 词：膝骨关节炎 骨痛灵酊 美洛昔康片 膝关节功能 步态功能 骨代谢指标 

分 类 号：R684.3[医药卫生—骨科学]