慢性肾功能不全患者NT-proBNP、CREA水平变化及临床意义  

Changes and Clinical Significance of NT-proBNP and CREA Levels in Patients with Chronic Renal Insufficiency

作　　者：陈崇纯 CHEN Chongchun(Shenzhen University General Hospital,Shenzhen 518000,China)

机构地区：[1]深圳大学总医院,广东深圳518000

出　　处：《中外医学研究》2024年第7期62-65,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨慢性肾功能不全(CRI)患者氨基末端B型利钠肽前体(NT-proBNP)、肌酐(CREA)水平变化及临床意义。方法:选取2018年7月—2023年6月深圳大学总医院收治的86例CRI患者作为观察组,另选取同期接受体检的100例健康者作为对照组,比较两组NT-proBNP、CREA、肾小球滤过率(GFR)水平,并比较观察组不同病情时期指标水平差异,分析NT-proBNP、CREA水平与GFR的相关性。采用受试者工作特征(ROC)曲线分析NT-proBNP、CREA诊断CRI的价值。结果:观察组NT-proBNP、CREA水平较对照组更高,GFR更低,差异有统计学意义(P<0.05)。肾功能衰竭终末期患者NT-proBNP、CREA水平与肾功能不全失代偿期、肾功能衰竭期患者相比更高,肾功能衰竭期患者与肾功能不全失代偿期患者相比更高,差异有统计学意义(P<0.05)。Pearson相关性分析显示,NT-proBNP、CREA水平与CRI患者的GFR呈负相关(r=-0.334、-0.326,P<0.05);ROC曲线显示,NT-proBNP、CREA诊断CRI的曲线下面积分别为0.786、0.735。结论:NT-proBNP、CREA在CRI患者体内的水平偏高,且与病情严重程度呈正相关,应用于CRI病情诊断具有较高的诊断价值。Objective:To explore the changes and clinical significance of N-terminal pro B-type natriuretic peptide(NT-proBNP)and creatinine(CREA)levels in patients with chronic renal insufficiency(CRI).Method:A total of 86 patients with CRI admitted to the Shenzhen University General Hospital from July 2018 to June 2023 were selected as the observation group,and 100 healthy subjects who underwent physical examination during the same period were selected as the control group.The levels of NT-proBNP,CREA and glomerular filtration rate(GFR)between the two groups were compared,and the levels of indicators in different disease periods of the observation group were compared.The correlation between NT-proBNP,CREA and GFR was analyzed.Receiver operating characteristic(ROC)curve was used to analyze the value of NT-proBNP and CREA in diagnosing CRI.Result:The levels of NT-proBNP and CREA in the observation group were higher than those in the control group,and the GFR was lower,the differences were statistically significant(P<0.05).The levels of NT-proBNP and CREA in end-stage patients with renal failure were higher than those in patients with renal insufficiency decompensation stage and renal failure stage,and which in patients with renal failure stage were higher than those in patients with renal insufficiency decompensation stage,and the differences were statistically significant(P<0.05).Pearson correlation analysis showed that NT-proBNP and CREA levels were negatively correlated with GFR in patients with CRI(r=-0.334,-0.326,P<0.05).ROC curve showed that the area under the curve of NT-proBNP and CREA for diagnosis of CRI was 0.786 and 0.735,respectively.Conclusion:The levels of NT-proBNP and CREA in CRI patients are relatively high,and are positively correlated with the severity of the condition.They were applied to the diagnosis of CRI conditions has high diagnostic value.

关 键 词：慢性肾功能不全 氨基末端B 型利钠肽前体 肌酐 

分 类 号：R692[医药卫生—泌尿科学]