奥曲肽治疗头颈部恶性肿瘤颈淋巴清扫术后高流量复杂性乳糜瘘1例  

Octreotide in the treatment of high flow and complex chylous fistula after neck dissection for head and neck cancer:a case report

作　　者：黄静 张欢 岳姣 马棪斐 林瑶 HUANG Jing;ZHANG Huan;YUE Jiao;MA Yanfei;LIN Yao(State Key Laboratory for Oral&Maxillofacial Reconstruction and Regeneration,National Clinical Research Center of Oral Diseases,Shaanxi Engineering Research Center of Dental Materials and Advanced Manufacture,Department of Pharmacy,The Third Affiliated Hospital of Air Force Medical University,Shaanxi Xi’an 710032,China)

机构地区：[1]口颌系统重建与再生全国重点实验室,国家口腔疾病临床医学研究中心,陕西省口腔生物工程技术研究中心,空军军医大学第三附属医院药剂科,陕西西安710032

出　　处：《中国医院药学杂志》2024年第5期607-610,共4页Chinese Journal of Hospital Pharmacy

摘　　要：目的:通过分析1例奥曲肽治疗头颈部恶性肿瘤颈淋巴清扫术后高流量复杂性乳糜瘘的案例,为头颈部恶性肿瘤颈淋巴清扫术后乳糜瘘的治疗方案提供参考。方法:对1例头颈部恶性肿瘤颈淋巴清扫术后高流量复杂性乳糜瘘患者的临床表现、发病原因、初始及复发后治疗方案结合相关文献进行分析。结果:患者首次确诊乳糜瘘时,经全肠外营养、加压包扎及负压创面治疗技术治疗后好转出院,再次复发入院时虽然从入院开始即给予全肠外营养和加压包扎的常规治疗,但乳糜瘘在联合奥曲肽治疗10 d后才得到控制,故将该病例的治愈归因于奥曲肽的使用。结论:奥曲肽对于头颈部恶性肿瘤颈淋巴清扫术后高流量复杂性乳糜瘘的治疗具有较好的前景,但可能存在其他混杂因素的影响,尚需开展多中心、更大样本量的随机对照试验进行验证。OBJECTIVE To analyze a case of high flow complex chylous fistula with octreotide treatment and provide reference for the management of chylous fistula following neck dissection for head and neck cancer.METHODS The clinical manifestations,causes,initial and post-recurrence treatment in a case of high flow and complex chylous fistula following neck dissection for head and neck cancer were analyzed in combination with related literature.RESULTS The patient was discharged from hospital after treatment with total parenteral nutrition,pressure dressing and negative pressure wound treatment when first diagnosed with chylous fistula.Although the conventional treatment of total parenteral nutrition and pressure dressing was given from the beginning of admission when chylous fistula recurred,it was controlled after 10-day octreotide treatment,therefore the successful treatment of chylous fistula was contributed to octreotide.CONCLUSION Octreotide has a good prospect in the treatment of high flow complex chylous fistula following neck dissection for head and neck cancer,however,other confounding factors may be involved.Our findings need to be verified in large-scale,randomized,multi-center trials.

关 键 词：奥曲肽 颈淋巴清扫术 高流量复杂性乳糜瘘 

分 类 号：R97[医药卫生—药品]