IL-33/ST2信号通路影响干细胞功能的研究进展  

Research Progress on the Effect of IL-33/ST2 Signaling Pathway on Stem Cell Function

作　　者：徐文杰 华进联[1] XU Wen-Jie;HUA Jin-Lian(Shaanxi Stem Cell Engineering and Technology Research Center,College of Veterinary Medicine,Northwest A&F University,Yangling 712100,China)

机构地区：[1]西北农林科技大学动物医学院陕西省干细胞工程技术研究中心,杨凌712100

出　　处：《农业生物技术学报》2024年第4期892-902,共11页Journal of Agricultural Biotechnology

基　　金：国家自然科学基金(32072806,32372970);国家重点研发计划(2022YFD1302201);陕西省重点研发计划(2022NY-044);陕西省畜牧专项(20221086,20230978)。

摘　　要：白细胞介素-33(interleucin 33,IL-33)是一种兼有促炎与抑炎功能的细胞因子,通过其特异性受体—肿瘤抑制因子2(suppressor of tumorigenicity 2,ST2)实现信号传导。IL-33/ST2信号通路的激活根据细胞类型的差异,调控NF-κb、TNFα、Wnt等信号通路,进而引发炎症反应以及影响干细胞的干性与分化能力。本文综述了IL-33/ST2信号通路的基本结构与组成,并且概括与之相关的干细胞功能研究的最新进展。本文通过作用机理的阐明为干细胞治疗炎症性疾病与免疫性疾病提供新思路。Interleucin 33(IL-33)is a cytokine with both pro-inflammatory and anti-inflammatory functions,and its signaling is mediated through its specific receptor suppressor of tumorigenicity 2(ST2).Activation of the IL-33/ST2 signaling pathway regulates NF-κb,TNFα,and Wnt signaling pathways depending on the cell type,thereby triggering inflammatory response and affecting the stemness and differentiation of stem cells.In this paper,the basic structure and composition of the IL-33/ST2 signaling pathway were reviewed,and the recent progress in stem cell function research was summarized.This review provides new ideas for the treatment of inflammatory and immune diseases by elucidating the mechanism of action of stem cells.

关 键 词：IL-33/ST2信号通路 干细胞 癌症干细胞 细胞治疗 炎症 

分 类 号：S852[农业科学—基础兽医学] Q26[农业科学—兽医学]