中性粒细胞/淋巴细胞比值对过敏性紫癜患儿肾脏受累的诊断价值  

The diagnostic value of neutrophil/lymphocyte ratio for renal involvement in children with anaphylactoid purpura

作　　者：王香敏 鲍士莉 魏海燕 WANG Xiangmin;BAO Shili;WEI Haiyan(Department of Pediatrics,Huainan First People’s Hospital,the First Affiliated Hospital,Anhui University of Technology,Huainan 232000,Anhui,China)

机构地区：[1]安徽理工大学第一附属医院,淮南市第一人民医院儿科,安徽淮南232000

出　　处：《中南医学科学杂志》2024年第2期268-271,共4页Medical Science Journal of Central South China

基　　金：阜阳市科技计划项目(FK202081013)。

摘　　要：目的探讨中性粒细胞/淋巴细胞比值(NLR)对过敏性紫癜(AP)患儿肾脏受累的诊断价值。方法选择AP患儿103例为AP组,根据是否出现肾脏受累分为受累组(n=41)和无受累组(n=62),另选同期健康体检人群74例为对照组。比较各组一般资料及NLR。采用ROC评估NLR对AP患儿肾脏受累的诊断价值,采用多因素Logistic回归分析影响AP患儿肾脏受累的危险因素。结果AP组外周血中性粒细胞、NLR高于对照组,淋巴细胞低于对照组,受累组外周血中性粒细胞、NLR均明显高于未受累组,淋巴细胞低于未受累组(P<0.05)。胱抑素C、中性粒细胞、淋巴细胞及NLR均为AP患儿肾脏受累的危险因素(P<0.05)。中性粒细胞、淋巴细胞和NLR对AP患儿肾脏受累具有良好的诊断效能。结论NLR是AP患儿肾脏受累的危险因素,NLR可作为诊断AP患儿肾脏受累的有效指标。Aim To explore the diagnostic value of neutrophil/lymphocyte ratio(NLR)in renal involvement in children with anaphylactoid purpura(AP).Methods A total of 103 AP children were selected as AP group and divided into an involved group(n=41)and an uninvolved group(n=62)according to renal involvement,and 74 healthy people were selected as control group.The general data and NLR of each group were compared.ROC was used to evaluate the diagnostic value of NLR for renal involvement in children with AP,and multivariate Logistic regression was used to analyze the risk factors affecting renal involvement in children with AP.Results Peripheral blood neutrophils and NLR in AP group were higher than those in control group,and lymphocytes were lower than those in control group.Peripheral blood neutrophils and NLR in involved group were significantly higher than those in non-involved group,and lymphocytes were lower than those in non-involved group(P<0.05).Cystatin C,neutrophils,lymphocytes and NLR were risk factors for renal involvement in children with AP(P<0.05).Neutrophils,lymphocytes and NLR have good predictive efficacy for renal involvement in children with AP.Conclusion NLR is a risk factor for renal involvement in children with acute pancreatitis,and NLR can be used as an effective indicator to predict renal involvement in AP children.

关 键 词：中性粒细胞/淋巴细胞比值 过敏性紫癜 儿童 肾脏受累 

分 类 号：R725[医药卫生—儿科]