甲磺酸非诺多泮合成工艺研究进展  

Synthetic Process Analysis of Fenodopam Mesylate

作　　者：李洪发 莫洪虎 李润璞 孟祥丽[1,2] Li Hongfa;Mo Honghu;Li Runpu;Meng Xiangli(Mudanjiang Medical College,Heilongjiang,157011;Mudanjiang Medical College Affi liated Hongqi Hospitai,Heilongjiang,157011)

机构地区：[1]牡丹江医学院,黑龙江157011 [2]牡丹江医学院附属红旗医院,黑龙江157011

出　　处：《当代化工研究》2024年第6期15-17,共3页Modern Chemical Research

基　　金：黑龙江省卫计委资助项目“非诺多泮制备工艺中试放大研究”(项目编号:2017-354)。

摘　　要：甲磺酸非诺多泮(Fenodopam Mesylate)由于性质稳定、疗效可靠,安全性高、不良反应甚微等优势是目前用于重症高血压治疗效果较好的药物。本文综述了甲磺酸非诺多泮的合成路线,并对其优缺点进行分析,为后续合成工艺优化提供支持,以便得到操作简单、经济高效、绿色环保的工业化生产路线。Fenodopam mesylate is an effective drug in the treatment of severe hypertension because of its stable nature,reliable efficacy,high safety and few adverse reactions.In this paper,the synthetic route of fenodopam mesylate was reviewed,and its advantages and disadvantages were analyzed to provide support for the follow-up synthesis process optimization,and the industrial production route with simple operation,economic efficiency and green environmental protection was obtained.

关 键 词：甲磺酸非诺多泮 中间体 合成工艺 

分 类 号：TQ460[化学工程—制药化工]