缺血性中风后中枢神经系统与免疫系统的交互作用机制及其中药干预研究进展  

Interaction between central nervous system and immune system afterischemic stroke and its therapeutic significance of traditional Chinese medicine

作　　者：王欢欢[1,2] 孟凡征 唐仕欢[2] 吴宏伟[2] 杨洪军[2] WANG Huan-huan;MENG Fan-zheng;TANG Shi-huan;WU Hong-wei;YANG Hong-jun(Hospital of Integrated Chinese and Western Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 300100,China;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]天津中医药大学中西医结合医院,天津300100 [2]中国中医科学院中药研究所,北京100700

出　　处：《中国中药杂志》2024年第5期1154-1163,共10页China Journal of Chinese Materia Medica

基　　金：国家重点研发计划项目(2019YFC1708900)。

摘　　要：缺血性中风分为急性期、亚急性期、恢复期,不同的阶段具有不同病理生理特征,其中免疫与炎症反应在缺血后的数天和数周内持续存在。缺血性中风不仅在受损大脑区域引发局部炎症,还会诱导免疫系统紊乱,进而促进神经炎症,加剧脑损伤。因此,对缺血性中风后中枢神经系统与免疫系统相互影响进行深入分析,对其相互作用的主要因素进行干预,阻断病理级联反应、减轻脑部炎症,成为缺血性中风的治疗策略之一。该文对中枢神经系统与免疫系统的交互作用途径进行总结梳理,从自主神经系统、下丘脑-垂体-肾上腺轴(the hypothalamic-pituitary-adrenal axis,HPA)、局部炎症解析中枢神经系统对免疫系统的影响,从免疫细胞的动态变化解析免疫系统对中枢神经系统的影响。同时,总结中医药防治的相关进展,为中药防治缺血性中风的复杂作用机制解析提供新思路。Ischemic stroke is divided into acute phase,subacute phase,and recovery phase,with different pathological and physiological characteristics manifested at each stage.Among them,immune and inflammatory reactions persist for several days and weeks after ischemia.Ischemic stroke not only triggers local inflammation in damaged brain regions but also induces a disorder in the immune system,thereby promoting neuroinflammation and exacerbating brain damage.Therefore,conducting an in-depth analysis of the interaction between the central nervous system and the immune system after ischemic stroke,intervening in the main factors of the interaction between them,blocking pathological cascades,and thereby reducing brain inflammation have become the treatment strategies for ischemic stroke.This study summarizes and sorts out the interaction pathways between the central nervous system and the immune system.The impact of the central nervous system on the immune system can be analyzed from the perspective of the autonomic nervous system,the hypothalamic-pituitary-adrenal axis(HPA),and local inflammatory stimulation.The impact of the immune system on the central nervous system can be analyzed from the dynamic changes of immune cells.At the same time,the relevant progress in the prevention and treatment of traditional Chinese medicine(TCM)is summarized,so as to provide new insights for the analysis of complex mechanisms of TCM in preventing and treating ischemic stroke.

关 键 词：缺血性中风 免疫与炎症 中枢神经系统 免疫系统 

分 类 号：R285[医药卫生—中药学]