植物环肽研究进展  

Advances on cyclopeptides of plants

作　　者：赵冕 王磊[1] 冯子迈 蔡乐[3] 贾庆忠[2] ZHAO Mian;WANG Lei;FENG Zi-mai;CAI Le;JIA Qing-zhong(Experimental Center for Teaching,Hebei Medical University,Shijiazhuang 050017,China;College of Pharmacy,Hebei Medical University,Shijiazhuang 050017,China;School of Chemical Science and Technology,Yunnan University,Kunming 650091,China)

机构地区：[1]河北医科大学教学实验中心,河北石家庄050017 [2]河北医科大学药学院,河北石家庄050017 [3]云南大学化学科学与工程学院,云南昆明650091

出　　处：《中国中药杂志》2024年第5期1172-1185,共14页China Journal of Chinese Materia Medica

基　　金：河北省自然科学基金重点项目(H2021206352);云南省科技厅-云南大学“双一流”建设联合专项-重大项目(202201BF070001-014);河北医科大学国家级大学生创新性实验计划项目(USIP2023017)。

摘　　要：植物环肽是一类主要由氨基酸肽键形成的环状含氮化合物,一般包含2~37个L-构型的编码或者非编码氨基酸结构单元,是具有重要研究价值的天然植物小分子代谢产物。科学研究表明,此类天然产物在各科植物中广泛分布,化学成分主要包括环二肽类、环四肽类、环五肽类、环六肽类、环七肽类、环八肽类、环九肽类、环十肽类等,其中环二肽类、环六肽类、环八肽类是其主要活性成分。据报道,植物环肽结构新奇、独特,具有抗肿瘤、抗菌、抗疟、抗炎、抗病毒等多种药理活性。该文对2006年以来植物环肽的研究成果进行了综述,以期为植物环肽及其在相关医药、卫生、农业等领域的进一步研究提供理论参考。Cyclopeptides isolated from a variety of plants are a class of cyclic nitrogen-containing compounds,and they are primarily formed by peptide bonds between amino acids,generally containing 2 to 37 L-configuration encoded or non-encoded amino acid residues.Cyclopeptides have significant values in scientific research as natural small-molecule metabolites produced by plants.The available studies have revealed that such natural products are ubiquitous in plants,which mainly include cyclic dipeptides,cyclic tetrapeptides,cyclic pentapeptides,cyclic hexapeptides,cyclic heptapeptides,cyclic octapeptides,cyclic nonapeptides,and cyclic decapeptides.Among them,cyclic dipeptides,cyclic hexapeptides,and cyclic octapeptides are the major active compounds.It has been reported that plant cyclopeptides have novel and unique chemical structures.They possess diverse pharmacological activities,such as antineoplastic,antimicrobial,antimalarial,anti-inflammatory,and antiviral activities.This paper summarizes the research achievements of plant cyclopeptides since 2006,aiming to provide theoretical reference for the research and application of plant cyclopeptides in medicine,health,and agriculture fields.

关 键 词：植物 环肽 化学成分 药理活性 

分 类 号：R284[医药卫生—中药学]