辣椒辣素在神经病理性疼痛方面的作用机制及应用研究进展  

Mechanism and application of capsaicin in neuropathic pain:a literature review

作　　者：吕传宝 董英伟[2] Lyu Chuanbao;Dong Yingwei(Department of Anesthesiology,The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou City,Guangdong Province 510000,China;Department of Anesthesiology,First Affiliated Hospital of Harbin Medical University,Harbin City,Heilongjiang Province 150000,China)

机构地区：[1]广州中医药大学附属第一医院麻醉科,广州市510000 [2]哈尔滨医科大学附属第一医院麻醉科,哈尔滨市150000

出　　处：《中华疼痛学杂志》2024年第1期127-130,共4页Chinese Journal Of Painology

摘　　要：辣椒辣素是从红辣椒里提取的镇痛物质,其单次腹腔注射镇痛作用时间长达半年(新生鼠)至1年(成熟大鼠),近年来引起广泛关注,成为研究热点。大量临床研究表明,辣椒辣素可以减轻神经病理性疼痛,使患者在行走、工作和睡眠方面均得到改善。因此,辣椒辣素有潜力成为治疗神经病理性疼痛的一线或二线药物。Capsaicin is an analgesic substance extracted from red pepper.The analgesic effect of capsaicin can last half a year(newborn rats)to one year(mature rats)by single intraperitoneal injection.In recent years,capsaicin has attracted wide attention and become a research hotspot.Many clinical studies have shown that capsaicin can relieve neuropathic pain and improve patients'walking,work and sleep.Capsaicin has great potential to become a first-or second-line medicine for the treatment of neuropathic pain.

关 键 词：神经痛 辣椒辣素 香草酸瞬时受体亚型1 镇痛 

分 类 号：R614[医药卫生—麻醉学]