血清S100钙结合蛋白A12、可溶性晚期糖基化终末产物受体水平与维持性血液透析患者骨质疏松的相关性分析  

Correlation analysis of serum S100 calcium binding protein A12 and soluble advanced glycation end-product receptor levels with osteoporosis in maintenance hemodialysis patients

作　　者：梁冰[1] 王萌萌 张靖华[1] Liang Bing;Wang Mengmeng;Zhang Jinghua(Kidney Transplant Kidney Disease Diagnosis and Treatment Center,the Seventh People’s Hospital of Zhengzhou,Zhengzhou 450016,China)

机构地区：[1]郑州市第七人民医院肾移植肾脏病诊疗中心,郑州450016

出　　处：《临床内科杂志》2024年第3期175-178,共4页Journal of Clinical Internal Medicine

基　　金：河南省医学科技攻关计划(联合共建)项目(LHGJ20191126)。

摘　　要：目的探讨维持性血液透析(MHD)患者血清S100钙结合蛋白A12(S100A12)、可溶性晚期糖基化终末产物受体(sRAGE)的水平变化及与骨质疏松的关系。方法选取2020年1月~2022年6月在本院血透室治疗的MHD患者110例,根据T值将其分为骨质疏松组(42例,T值≤-2.5 g/cm2)及非骨质疏松组(68例,T值>-2.5 g/cm2),同期选取在本院健康体检者50例为对照组。收集所有受试者的一般资料(性别、年龄、BMI、透析龄)及临床资料并进行组间比较。相关性分析采用Pearson相关分析。采用受试者工作特征(ROC)曲线评估血清sRAGE和S100A12水平对MHD患者骨质疏松的预测价值。采用多重线性回归分析探讨MHD患者发生骨质疏松的影响因素。结果与对照组相比,非骨质疏松组与骨质疏松组患者血钙、血磷、骨密度、sRAGE水平均降低,全段甲状旁腺激素(iPTH)、尿素氮(BUN)、血肌酐(SCr)、白蛋白(Alb)、S100A12水平均升高(P<0.05)。与非骨质疏松组相比,骨质疏松组患者血清iPTH、S100A12水平均升高,血磷、骨密度、sRAGE水平均降低(P<0.05)。Pearson相关分析结果显示,MHD患者血清sRAGE与S100A12表达呈负相关;血清sRAGE与血磷、骨密度均呈正相关,与iPTH呈负相关;血清S100A12与血磷、骨密度均呈负相关,与iPTH呈正相关(P<0.05)。ROC曲线分析结果显示,血清S100A12、sRAGE联合预测MHD患者骨质疏松的ROC曲线下面积(AUC)、特异度均高于二者单独预测。多重线性回归分析结果显示,MHD患者S100A12、sRAGE、iPTH均与骨质疏松发生有关(P<0.05)。结论MHD患者骨质疏松发生与sRAGE、S100A12密切相关,联合检测二者可作为诊断MHD患者骨质疏松发生的指标。Objective To investigate the changes of serum levels of S100 calcium binding protein A12(S100A12)and soluble advanced glycation end-product receptor(sRAGE)in maintenance hemodialysis(MHD)patients and their relationship with osteoporosis.Methods A total of 110 MHD patients treated in the hemodialysis room of our hospital from January 2020 to June 2022 were selected and divided into osteoporosis group(42 cases,T value≤-2.5 g/cm2)and non-osteoporosis group(68 cases,T value>-2.5 g/cm2)according to T value,and 50 healthy subjects in our hospital in the same period were selected as control group.General data(gender,age,BMI,dialysis age)and clinical data of all subjects were collected and compared between groups.Pearson correlation analysis was used for correlation analysis.The predictive value of serum sRAGE and S100A12 levels for osteoporosis in patients with MHD was evaluated by using receiver operating characteristic(ROC)curves.Multiple linear regression analysis was used to investigate the influencing factors of osteoporosis in MHD patients.Results Compared with control group,the levels of blood calcium,blood phosphorus,bone mineral density and sRAGE were decreased in non-osteoporosis group and osteoporosis group,while the levels of intact parathyroid hormone(iPTH),blood urea nitrogen(BUN),serum crea tinine(SCr),albumin(Alb)and S100A12 were increased(P<0.05).Compared with non-osteoporosis group patients,the serum levels of iPTH and S100A12 in osteoporosis group patients were increased,and the levels of blood phosphorus,bone mineral density and sRAGE were decreased(P<0.05).Pearson correlation analysis results showed that in MHD patients,serum sRAGE was negatively correlated with S100A12 expression;serum sRAGE was positively correlated with blood phosphorus and bone mineral density,but negatively correlated with iPTH;serum S100A12 was negatively correlated with blood phosphorus and bone mineral density,but positively correlated with iPTH(P<0.05).ROC curve analysis showed that the area under the ROC curve(AUC)and sp

关 键 词：维持性血液透析 骨质疏松 可溶性晚期糖基化终末产物受体 血清S100钙结合蛋白A12 

分 类 号：R459.5[医药卫生—治疗学] R446.11[医药卫生—临床医学]