Copper(Ⅰ)-catalyzed interrupted click/radical relay:A four-component modular synthesis of triazole sulfones  

作　　者：Pengfei Sun Fang Wei Chen-Ho Tung Zhenghu Xu 

机构地区：[1]Key Lab for Colloid and Interface Chemistry of Education Ministry,Shandong University,Ji'nan 250100,China [2]State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China [3]Functional Molecules of Zhejiang Province,School of Science,Westlake University,Hangzhou 310024,China [4]Key Laboratory of Organic Chemistry in Jiangxi Province,Institute of Organic Chemistry,Jiangxi Science&Technology Normal University,Nanchang 330013,China

出　　处：《Chinese Chemical Letters》2024年第3期247-251,共5页中国化学快报（英文版）

基　　金：financial support from the Natural Science Foundation of China and Shandong Province(Nos.21971149,92156007,ZR2019ZD45,ZR2020KB005);the Fundamental Research Funds of Shandong University。

摘　　要：A new,four component copper(Ⅰ)-catalyzed interrupted click/radical relay cascade has been developed.This unprecedented interrupted click reaction provides a rapid modular synthesis of triazole sulfones,important privileged heterocyclic pharmacophores which cannot be accessed by a traditional click reaction.Radical interception of cuprate-triazole,the key reaction intermediate formed in situ,is an important feature of this process.

关 键 词：Click reaction TRIAZOLE SULFONE Radical relay 

分 类 号：O626[理学—有机化学]