Phosphine-catalyzed acyl-transfer of heteroaryl ketones for the construction of N-fused heterocycles  

作　　者：Yu Zhang De-Rui Han Dan Ye Hong Lu Hao Wei 

机构地区：[1]Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education,College of Chemistry&Materials Science,Northwest University,Xi'an 710069,China

出　　处：《Chinese Chemical Letters》2024年第3期252-256,共5页中国化学快报（英文版）

基　　金：the financial support from the National Natural Science Foundation of China(Nos.21971205 and 22271231);the Natural Science Basic Research Plan in Shaanxi Province of China(No.2023-JC-YB-126);Natural Science Basic Research Plan for Distinguished Young Scholars in Shaanxi Province of China(No.2022JC-08);Key Research and Invention Program in Shaanxi Province of China(No.2021SF-299)。

摘　　要：An inexpensive phosphine catalyst was used effectively for a transition-metal-free acyl-transfer of N-containing heteroaryl ketones for the rapid synthesis of N-fused heterocycles.The key pre-aromatic spirocyclic intermediate initialized by the single electron transfer(SET)process of Togni's reagentⅡpromoted by the tertiary phosphine resulted in an intriguing and alternative tactic for the cleavage of C–C bonds.By using inexpensive tertiary phosphine as the catalyst,this skeleton-reorganizing approach of N-containing heteroaryl ketones allows a streamlined assembly of complex N-fused heterocycles with broad functional group tolerance.

关 键 词：Phosphine catalysis Acyl-transfer N-Fused heterocycles C–C bond activation AROMATIZATION 

分 类 号：O626[理学—有机化学]