De novo design of highly efficient type-Ⅰphotosensitizer based onπ-conjugated oligomer for photodynamic eradication of multidrug-resistant bacterial infections  

作　　者：Qi Zhao Guangchao Qing Jie Yu Ying Liu Jianliang Shen Yang Luo Xingjie Zan Shengliang Li 

机构地区：[1]State Key Laboratory of Ophthalmology,Optometry and Vision Science,School of Ophthalmology and Optometry,School of Biomedical Engineering,Wenzhou Medical University,Wenzhou Institute,University of Chinese Academy of Sciences,Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine,Vision and Brain Health),Wenzhou 325001,China [2]College of Pharmaceutical Sciences,Soochow University,Suzhou 215123,China [3]Center of Smart Laboratory and Molecular Medicine,School of Medicine,Chongqing University,Chongqing 400044,China [4]College of Life Science and Laboratory Medicine,Kunming Medical University,Kunming 650050,China

出　　处：《Chinese Chemical Letters》2024年第3期389-393,共5页中国化学快报（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(Nos.82125022,82072383,31800833,21977081,52173135 and 22207024);Zhejiang Provincial Natural Science of Foundation of China(No.LZ19H180001);Wenzhou Medical University(No.KYYW201901);University of Chinese Academy of Science(Nos.WIBEZD2017001-03 and WIUCASYJ2020001)。

摘　　要：Traditional photosensitizers show limited singlet oxygen generation in hypoxic infection lesions,which greatly suppress their performance in antibacterial therapy.Meanwhile,there still is lack of feasible design strategy for developing hypoxia-overcoming photosensitizers agents.Herein,radical generation ofπ-conjugated small molecules is efficiently manipulated by an individual selenium(Se)substituent.With this strategy,the first proof-of-concept study of a Se-anchored oligo(thienyl ethynylene)(OT-Se)with high-performance superoxide radical(O_(2)^(·-))and hydroxyl radical(·OH)generation capability is present,and achieves efficient antibacterial activities towards the clinically extracted multidrug-resistant bacteria methicillin-resistant S.aureus(MRSA)and carbapenem-resistant E.coli(CREC)at sub-micromolar concentration under a low white light irradiation(30 mW/cm^(2)).The water-dispersible OT-Se shows a good bacteria-anchoring capability,biocompatibility,and complete elimination of multidrug-resistant bacteria wound infection in vivo.This work offers a strategy to boost type-I photodynamic therapy(PDT)performance for efficient antibacterial treatments,advancing the development of antibacterial agents.

关 键 词：Photodynamic therapy Antibacterial Type-Ⅰphotosensitizers Multidrug-resistant bacteria Conjugated oligomers 

分 类 号：R91[医药卫生—药学] TQ422[化学工程]