Simple-structured hydrophilic sensors for sweat uric acid detection with laser-engraved polyimide electrodes and cellulose paper substrates  

作　　者：Linhe Xu Xueshan Hu Shuang Zhou Ze Zhang Junxian Zhang Chao Li Daxian Zuo Hao Liu Gang Chen Jiayu Wan Jinsong Tao 

机构地区：[1]State Key Lab of Pulp and Paper Engineering,South China University of Technology,Guangzhou 510640,China [2]Future Battery Research Center,Global Institute of Future Technology,Shanghai Jiao Tong University,Shanghai 200240,China

出　　处：《Chinese Chemical Letters》2024年第3期443-448,共6页中国化学快报（英文版）

基　　金：funded by Guangdong Basic and Applied Basic Research Foundation(No.2023A1515011388);Guangzhou City Industrial Science&Technology Projects(No.202201010059);the fund from Guangxi China Tobacco Industry Co.,Ltd.(No.2022450000340057);the fund for the construction of Bengbu-SCUT Research Center for Advanced Manufacturing of Biomaterials(No.20210190);The National Key Research and Development Program of China(No.2018YFC1902102)。

摘　　要：Accurate detection of uric acid(UA)is crucial for diagnosing gout,yet traditional sweat-based UA sensors continue to face challenges posed by complex and costly electrode fabrication methods,as well as weakly hydrophilic substrates.Here,we designed and developed simple,low-cost,and hydrophilic sweat UA detection sensors constructed by carbon electrodes and cellulose paper substrates.The carbon electrodes were made by carbonized polyimide films through a simple,one-step laser engraving method.Our electrodes are porous,possess a large specific surface area,and are flexible and conductive.The substrates were composed of highly hydrophilic cellulose paper that can effectively collect,store,and transport sweat.The constructed electrodes demonstrate high sensitivity of 0.4μA Lμmol^(-1)cm^(-2),wide linear range of 2–100μmol/L.In addition,our electrodes demonstrate high selectivity,excellent reproducibility,high flexibility,and outstanding stability against mechanical bending,temperature variations,and extended storage periods.Furthermore,our sensors have been proven to provide reliable results when detecting UA levels in real sweat and on real human skin.We envision that these sensors hold enormous potential for use in the prognosis,diagnosis,and treatment of gout.

关 键 词：Laser-engraved carbon POLYIMIDE Cellulose paper HYDROPHILICITY Sweat uric acid 

分 类 号：O657.1[理学—分析化学] R589.7[理学—化学]