吸烟成瘾与体重状态的交互作用对大脑活动影响的静息态功能磁共振成像研究  

Resting-state functional magnetic resonance imaging study on the interaction effects between smoking addiction and weight status on brain activity

作　　者：张孟哲 牛晓玉 党婧涵 孙洁萍 汪卫建 程敬亮[1] 张勇[1] Zhang Mengzhe;Niu Xiaoyu;Dang Jinghan;Sun Jieping;Wang Weijian;Cheng Jingliang;Zhang Yong(Department of MRI,First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院磁共振科,郑州450052

出　　处：《中华行为医学与脑科学杂志》2024年第3期240-245,共6页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：河南省重点研发与推广专项(科技攻关)支持项目(212102310712)。

摘　　要：目的利用静息态功能磁共振成像技术探讨吸烟成瘾与体重状态之间相互作用对大脑活动的影响。方法回顾性分析2019年1月至2021年12月招募的99名受试者的相关临床资料及静息态功能磁共振数据。所有被试分为4组:超重吸烟者(n=24),正常体重吸烟者(n=28),超重非吸烟者(n=19)和正常体重非吸烟者(n=28)。计算局部一致性(regional homogeneity,ReHo),来反映受试者大脑内部活动。使用SPM12软件,采用双因素方差分析,将年龄、受教育年限和头部运动作为协变量,分析吸烟成瘾与超重对于大脑活动的交互作用。结果吸烟成瘾与超重对右侧额上回(x,y,z=15,9,60)ReHo值存在交互作用(GRF校正,体素水平P<0.005,团块水平P<0.05)。超重吸烟者右侧额上回ReHo值显著高于正常体重吸烟者(t=3.768,P<0.001,Bonferroni校正)。超重非吸烟者右侧额上回ReHo值显著低于正常体重非吸烟者(t=-3.242,P=0.002,Bonferroni校正)。正常体重吸烟者右侧额上回ReHo值显著低于正常体重非吸烟者(t=-3.540,P=0.001,Bonferroni校正)。超重吸烟者右侧额上回ReHo值显著高于超重非吸烟者(t=3.392,P=0.002,Bonferroni校正)。相关分析显示,吸烟成瘾者右侧额上回ReHo值与吸烟指数呈正相关(r=0.387,P=0.007,Bonferroni校正)。结论吸烟成瘾与超重对右侧额上回的大脑活动存在拮抗作用,该机制可能为吸烟成瘾和超重共病的人群提供潜在的治疗靶点。ObjectiveTo explore the interaction effects on brain activity between the smoking addiction and weight status by resting-state functional magnetic resonance imaging.MethodsRetrospective analysis of clinical data and resting-state functional magnetic resonance imaging data were analyzed from 99 recruited subjects from January 2019 to December 2021.All participants were divided into four groups:overweight smokers(n=24),normal-weight smokers(n=28),overweight non-smokers(n=19),and normal weight non-smokers(n=28).Calculate regional homogeneity(ReHo)to reflect the internal brain activity of the subjects.Two-way ANOVA was used to detect the interaction effects between smoking addiction and overweight on ReHo by SPM12 software,correcting for age,years of education and head motion.ResultsThe interaction effect between smoking addiction and overweight on ReHo was significant in right superior frontal gyrus(x,y,z=15,9,60)(GRF corrected,P voxel<0.005,P cluster<0.05).The ReHo value in the right superior frontal gyrus of overweight smokers was significantly higher than that of normal weight smokers(t=3.768,P<0.001,Bonferroni corrected).The ReHo values in the right superior frontal gyrus of overweight non-smokers were significantly lower than those of normal weight non-smokers(t=-3.242,P=0.002,Bonferroni corrected).The ReHo values in the right superior frontal gyurs of normal-weight smokers were significantly lower than those of normal weight non-smokers(t=-3.540,P=0.001,Bonferroni corrected).The ReHo values in the right superior frontal gyrus of overweight smokers were significantly higher than those of overweight non-smokers(t=3.392,P=0.002,Bonferroni corrected).Correlation analyses showed that the strengthen ReHo value in right superior frontal gyrus was positively associated with pack-year in smoking addicts(r=0.387,P=0.007,Bonferroni corrected).ConclusionSmoking addiction and overweight have an antagonistic effect on brain activity in the right superior frontal gyrus,which may provide potential therapeutic targets for indi

关 键 词：吸烟 体重 局部一致性 静息态功能磁共振成像 交互作用 

分 类 号：R445.2[医药卫生—影像医学与核医学] R163[医药卫生—诊断学]