狼疮性肾炎患者尿N-乙酰-β-D-氨基葡萄糖苷酶与尿肌酐比值变化及其临床意义  

Change and its clinical significance of the ratio of N-acetyl-β-D-glocosaminidase to urine creatinine in patients with lupus nephritis

作　　者：周崇梅 赵少华[1] Zhou Chongmei;Zhao Shaohua(Department of Clinical Laboratory,Henan Provincial People's Hospital,Zhengzhou 450000,China)

机构地区：[1]河南省人民医院检验科,郑州450000

出　　处：《临床医学》2024年第1期9-11,共3页Clinical Medicine

摘　　要：目的探讨狼疮性肾炎(LN)患者尿N-乙酰-β-D-氨基葡萄糖苷酶(NAG)与尿肌酐(UCr)比值的变化及其临床意义。方法采用前瞻性研究纳入2020年12月至2022年12月于河南省人民医院接受治疗的80例系统性红斑狼疮患者作为研究对象,检测患者NAG与UCr水平,临床症状评估及实验室检查评估是否为LN将其分为LN组与非LN组;纳入同期40例健康体检者作为对照组,比较三组NAG/UCr表达,分析NAG/UCr表达与系统性红斑狼疮患者发生LN的相关性。结果经临床评估,80例系统性红斑狼疮患者中有43例发生LN,占53.75%(43/80);有37例未发生LN,占比46.25%(37/80)。LN组NAG、NAG/UCr高于非LN组与对照组,UCr低于非LN组与对照组,差异有统计学意义(P<0.05);非LN组NAG、NAG/UCr高于对照组,UCr低于对照组,差异有统计学意义(P<0.05)。经点二列相关性分析,NAG、NAG/UCr与LN的发生呈正相关(r>0,P<0.05),UCr与LN的发生呈负相关(r<0,P<0.05)。结论NAG/UCr在LN患者中呈高表达,与系统性红斑狼疮患者中LN的发生呈正相关,且NAG/UCr越高,发生LN的可能性越大。Objective To investigate the change of the ratio of N-acetyl-β-D-glocosaminidase(NAG)to urine creatinine(UCr)in patients with lupus nephritis(LN)and analyze its clinical significance.Methods A prospective study was conducted,including 80 patients with systemic lupus erythematosus who received treatment at Henan Provincial People's Hospital from December 2020 to December 2022 as the study subjects.The levels of NAG and UCr were detected,and the patients were divided into LN group and non LN group by clinical symptom evaluation and laboratory examination.Forty healthy individuals were included as a blank control group during the same period.The expression of NAG/UCr was compared among the three groups.The relationship between NAG/UCr expression and the occurrence of LN in patients with systemic lupus erythematosus was analyzed.Results sAfterclinical evaluation,43 cases out of 80 patients with systemic lupus erythematosus developed LN,accounting for 53.75%(43/80).There were 37 cases without LN,accounting for 46.25%(37/80).The levels of NAG and NAG/UCr in the LN group were higher than those in the non LN group and blank control group,while the level of UCr was lower than those in the non LN group and blank control group,with significant differences(P<0.05).The NAG,NAG/UCr levels in the non LN group were higher than those in the blank control group,while the UCr level was lower than that in the blank control group,with significant differences(P<0.05).Through point two column correlation analysis,NAG,NAG/UCr were positively correlated with the occurrence of LN(r>0,P<0.05),while UCr was negatively correlated with the occurrence of LN(r<0,P<0.05).Conclusions NAG/UCr is highly expressed in LN patients and positively y correlated with the eoccurrence of LN in patients with systemic lupus erythematosus.The higher the NAG/UCr,the greater the likelihood of LN occurrence.

关 键 词：狼疮性肾炎 尿N-乙酰-Β-D-氨基葡萄糖苷酶 尿肌酐 

分 类 号：R593.242[医药卫生—内科学]