配药机器人批量调配参数的优化  

Optimization of batch dispensing parameters for dispensing robots

作　　者：丁海文 童彤 杜黎黎 刘圣 DING Hai-wen;TONG Tong;DU Li-li;LIU Sheng(Department of Pharmacy,Anhui Provincial Hospital,the First Affiliated Hospital of USTC,Hefei 230001,China;Wuxi Anzhizhuo Medical Robot Co.,Ltd.,Wuxi 214000,Jiangsu Province,China)

机构地区：[1]中国科学技术大学附属第一医院(安徽省立医院)药学部,合肥230001 [2]无锡安之卓医疗机器人有限公司,江苏无锡214000

出　　处：《医疗卫生装备》2024年第2期35-40,共6页Chinese Medical Equipment Journal

基　　金：中央高校基本科研业务费专项资金资助项目(WK9110000073)。

摘　　要：目的:优化配药机器人批量调配参数,保证成品输液的标准化与同质化。方法:以不溶性微粒为考察指标,利用正交试验优化配药机器人批量调配过程中的推拉次数、静置时间、转针速度、溶媒体积、抽拉角度5种调配参数。比较于室温下调配0、2、4、6、8 h时的4种成品输液(泮托拉唑钠溶液、艾司奥美拉唑钠溶液、奥美拉唑钠溶液、艾普拉唑钠溶液)的外观性状、pH值、渗透压和不溶性微粒数;对比采用配药机器人调配和人工调配4种成品输液的空西林瓶内的药液残留量及批量调配效率。结果:优化后,配药机器人批量调配参数为推拉次数2次、静置时间5 s、转针速度慢速、溶媒体积6 mL、抽拉角度90°。室温下调配8 h时,艾普拉唑钠溶液颜色变为淡黄色澄清,不溶性微粒数超出2020年版《中国药典》规定;其他3种成品输液0、2、4、6、8 h时外观性状均为无色澄清,不溶性微粒数均符合2020年版《中国药典》规定。4种成品输液0、2、4、6、8 h时pH值、渗透压均无显著变化。配药机器人调配的药液残留量显著低于人工调配,1人操作2台机器人的批量调配效率高于1人手工及1人操作1台机器人的批量调配效率,差异有统计学意义(P<0.05)。结论:采用正交试验优化配药机器人批量调配参数,保证了成品输液的标准化与同质化,可降低药液残留,提高批量调配效率。Objective To optimize the batch dispensing parameters of dispensing robots to ensure the standardization and homogenization of finished infusion.Methods Five parameters for intelligent dispensing robots were optimized with orthogonal test including push and pull times,standing time,needle rotation speed,solvent volume and pulling angle,with the insoluble particles as the evaluation index.Four finished infusion solutions including pantoprazole sodium solution,esomeprazole sodium solution,omeprazole sodium solution and eplazole sodium solution prepared at room temperature for 0,2,4,6 and 8 h were compared in terms of appearance,pH,osmolality and number of insoluble particles;the amounts of drug residue in empty syringe bottles and the efficiency of batch dispensing of the four finished infusion solutions using dispensing robot and manual operation were observed.Results After optimization the batch dispensing parameters of the robot were set as 2 times(push and pull times),5 s(standing time),low speed(needle rotation speed),6 mL(solvent volume)and 90°(pulling angle).After 8 h of dispensing at room temperature,the eplazole sodium solution became light yellow and clarified,and the number of insoluble particles went beyond the prescribed value in Chinese Pharmacopoeia 2020;the remained three solutions were colorless and clarified at 0,2,4,6 and 8 h,and the number of insoluble particles complied with the requirements of Chinese Pharmacopoeia 2020;there were no significant changes in pH and osmolality at 0,2,4,6 and 8 h.The robot had less drug residue than manual operation,and the efficiency of two robots operated by one person was higher than that of one person manually or one robot by one person,and all the differences were statistically significant(P<0.05).Conclusion The batch dispensing parameters optimized with orthogonal test contributes to the standardization and homogeneity of the finished solutions with decreased drug residue while increased batch dispensing efficiency.

关 键 词：配药机器人 调配参数 批量调配 不溶性微粒 

分 类 号：TP242[自动化与计算机技术—检测技术与自动化装置] R95[自动化与计算机技术—控制科学与工程]