葛根素治疗2型糖尿病及其并发症的研究进展  

Research Progress of Puerarin in Treatment of Type 2 Diabetes and its Complications

作　　者：苏清雅 张鑫[1] 廖琪欣 程龙 Su Qingya;Zhang Xin;Liao Qixin;Cheng Long(Department of Traditional Chinese Medicine and Pharmacognosy,China Medical University,Shenyang 110122,Liaoning,China)

机构地区：[1]中国医科大学中药与生药教研室,辽宁沈阳110122

出　　处：《贵州中医药大学学报》2024年第2期70-76,共7页Journal of Guizhou University of Traditional Chinese Medicine

基　　金：辽宁省博士科研启动基金计划项目,项目编号:2023-BS-093;2023年辽宁省大学生创新创业训练计划项目,项目编号:202310159022。

摘　　要：2型糖尿病(type 2 diabetes mellitus,T2DM)是常见的慢性代谢性疾病,其特征是高血糖和胰岛素抵抗,常伴随严重的并发症,致死率和致残率逐年增高。使用常规降糖药多伴有不良反应,如二甲双胍会引起呕吐、腹泻等胃肠道反应,寻找毒副作用小的“降糖”药是亟待解决的社会重大公共健康问题。传统中医药治疗T2DM有独特优势,安全有效。葛根素是中药葛根的主要活性成分,现代药理学研究和临床案例发现,葛根素在T2DM及其并发症的治疗过程中展现出良好的治疗效果。本文对葛根素治疗T2DM及其并发症的作用机制进行综述,丰富葛根素治疗糖尿病的理论依据,以期推动降糖新药研发。Type 2 diabetes mellitus(T2DM) is a common chronic metabolic disease characterized by hyperglycemia and insulin resistance. It is often accompanied by serious complications, and the mortality and disability rate increase year by year. Conventional hypoglycemic drugs are often accompanied by serious adverse reactions, such as metformin, which can cause gastrointestinal reactions such as vomiting and diarrhea. To search for effective Chinese medicine to "reduce glucose" is a major public health issue that needs to be solved urgently. Traditional Chinese medicine has unique advantages in treating T2DM, which is safe and effective. Puerarin is the main active ingredient of Pueraria lobata(Willd.) Ohwi. Modern pharmacological research and clinical cases found that puerarin has a significant therapeutic effect on the treatment of T2DM and its complications. In this article, the mechanism of puerarin in treating T2DM and its complications was reviewed to enrich the theoretical basis of puerarin in treating diabetes, in order to promote the research and development of new hypoglycemic drugs.

关 键 词：葛根素 葛根 2型糖尿病 糖尿病并发症 高血糖 胰岛素抵抗 作用机制 综述 

分 类 号：R285.6[医药卫生—中药学] R587.2[医药卫生—中医学]