TIMP-1 and its potential diagnostic and prognostic value in pulmonary diseases  

作　　者：Sultan Almuntashiri Abdullah Alhumaid Yin Zhu Yohan Han Saugata Dutta Ohmed Khilji Duo Zhang Xiaoyun Wang 

机构地区：[1]Clinical and Experimental Therapeutics,Department of Clinical and Administrative Pharmacy,College of Pharmacy,University of Georgia and Charlie Norwood VA Medical Center,Augusta,GA 30912,USA 2 Department of Clinical Pharmacy,College of Pharmacy,University of Hail,Hail 55473,Saudi Arabia 3 Department of Emergency Medicine,Medical College of Georgia,Augusta University,Augusta,GA 30912,USA 4 Department of Medicine,Medical College of Georgia,Augusta University,Augusta,GA 30912,USA

出　　处：《Chinese Medical Journal Pulmonary and Critical Care Medicine》2023年第2期67-76,共10页呼吸与危重症医学（英文）

基　　金：The Genotype-Tissue Expression(GTEx)Project was supported by the Common Fund of the Office of the Director of the National Insti-tutes of Health(NIH),and by National Cancer Institute(NCI),National Human Genome Research Institute(NHGRI),National Heart,Lung,and Blood Institute(NHLBI),National Institute on Drug Abuse(NIDA),Na-tional Institute of Mental Health(NIMH),and National Institute of Neu-rological Disorders and Stroke(NINDS).The data used for the analyses described in Fig.1 A were obtained from the GTEx Portal of The Human Protein Atlas on 02/28/2023.

摘　　要：Tissue inhibitors of metalloproteases(TIMPs)have caught the attention of many scientists due to their role in various physiological and pathological processes.TIMP-1,2,3,and 4 are known members of the TIMPs family.TIMPs exert their biological effects by,but are not limited to,inhibiting the activity of metalloproteases(MMPs).The balance between MMPs and TIMPs is critical for maintaining homeostasis of the extracellular matrix(ECM),while the imbalance between MMPs and TIMPs can lead to pathological changes,such as cancer.In this re-view,we summarized the current knowledge of TIMP-1 in several pulmonary diseases namely,acute lung injury(ALI)/acute respiratory distress syndrome(ARDS),pneumonia,asthma,chronic obstructive pulmonary disease(COPD),cystic fibrosis,and pulmonary fibrosis.Considering the potential of TIMP-1 serving as a non-invasive di-agnostic and/or prognostic biomarker,we also reviewed the circulating TIMP-1 levels in translational and clinical studies.

关 键 词：METALLOPROTEASES Extracellular matrix Chronic obstructive pulmonary disease Idiopathic pulmonary fibrosis Cystic fibrosis Lung injury 

分 类 号：R563[医药卫生—呼吸系统]