^(18)F-脱氧葡萄糖PET/CT两种评估方法对弥漫性大B细胞淋巴瘤患者化疗中期疗效评估及对预后预测价值  

Value of two methods of ^(18)F-fluorodeoxyglucose PET/CT in the evaluation of interim therapeutic efficacy and prognosis of diffuse large B-cell lymphoma

作　　者：侯丽杰 陆国秀 李妁 王明丽 阮超 郝珊瑚 HOU Li-jie;LU Guo-xiu;LI Shuo;WANG Ming-li;RUAN Chao;HAO Shan-hu(Postgraduate Training Base of General Hospital of Northern Theater Command of Dalian Medical University,Shenyang 110016,China;Nuclear Medicine Department,General Hospital of Northern Theater Command,Shenyang 110016,China;Postgraduate Training Base of General Hospital of Northern Theater Command of China Medical University,Shenyang 110016,China)

机构地区：[1]大连医科大学北部战区总医院研究生培养基地,辽宁沈阳110016 [2]北部战区总医院核医学科,辽宁沈阳110016 [3]中国医科大学北部战区总医院研究生培养基地,辽宁沈阳110016

出　　处：《临床军医杂志》2024年第3期240-243,247,共5页Clinical Journal of Medical Officers

基　　金：辽宁省民生科技计划联合计划项目(2021JH2/10300098)。

摘　　要：目的探讨^(18)F-脱氧葡萄糖(^(18)F-FDG)PET/CT中的Deauville五分法、ΔSUVmax法对弥漫性大B细胞淋巴瘤(DLBCL)患者化疗中期评估效能及对化疗12个月后的疗效预测价值。方法回顾性分析自2019年4月至2022年11月北部战区总医院收治的42例DLBCL患者的临床资料和影像资料。采用受试者工作特征(ROC)曲线分析ΔSUVmax%判断疗效的最佳截断值。以Lugano评估标准为“金标准”,分析Deauville五分法、ΔSUVmax法与Lugano评估标准评价化疗中期疗效的一致性。比较ΔSUVmax法与Deauville五分法的敏感性、特异性。分析Deauville五分法、ΔSUVmax法预测化疗12个月后疾病缓解情况。结果Deauville五分法与Lugano评估标准一致性检验Kappa值为0.538(P=0.011)。ΔSUVmax法与Lugano评估标准一致性检验Kappa值为0.769(P<0.001)。ΔSUVmax法敏感性为83.33%、特异性为93.33%,分别高于Deauville五分法的50.00%、82.35%,但差异无统计学意义(P>0.05)。Deauville五分法:阴性患者12个月后完全缓解率为70.59%(12/34),高于阳性患者的25.00%(2/8),差异有统计学意义(P<0.05)。ΔSUVmax法:阴性患者12个月后完全缓解率为80.00%(24/30),高于阳性患者的16.67%(2/12),差异有统计学意义(P<0.05)。结论基于中期PET/CT的视觉分析Deauville五分法和半定量分析ΔSUVmax法对DLBCL患者中期化疗效果评估价值及对化疗12个月后的疗效预测价值均较高,且ΔSUVmax法与Lugano评估标准一致性更高。Objective To investigate the efficacy of ^(18)F-fluorodeoxyglucose(^(18)F-FDG)PET/CT Deauville 15-point scale andΔSUVmax%method in the interim evaluation of chemotherapy in patients with diffuse large B-cell lymphoma(DLBCL)and the value of predicting the curative effect in patients after 12 monthes.Methods The clinical and imaging data of 42 DLBCL patients admitted to General Hospital of Northern Theater Command from April 2019 to November 2022 were retrospectively analyzed.Receiver operating characteristic(ROC)curve analysis was used to classify the optimal cut-off value ofΔSUVmax%for determining the curative effect.Lugano evaluation standard as the"gold standard",the consistency of Deauville 5-point scale method,ΔSUVmax method and Lugano criteria for evaluation of patients′interim chemotherapy treatment was compared.The sensitivity and specificity ofΔSUVmax method and Deauville 5-point scale method were compared.The Deauville 5-point scale method andΔSUVmax method were analyzed to predict disease remission after 12 months.Results The Kappa value of the consistency test between Deauville 5-point scale and Lugano evaluation criteria was 0.538(P=0.011).The Kappa value of the consistency test betweenΔSUVmax method and Lugano evaluation criteria was 0.769(P<0.001).The sensitivity and specificity of ΔSUVmax method were 83.33%and 93.33%,respectively higher than those of Deauville 5-point scale(50.00%and 82.35%),but the difference was not statistically significant(P>0.05).Deauville 5-point scale method:the complete remission rate of negative patients was 70.59%(12/34)after 12 months,which was higher than that of positive patients(25.00%,2/8),and the difference was statistically significant(P<0.05).ΔSUVmax method:the complete remission rate of negative patients after 12 months was 80.00%(24/30),higher than that of positive patients(16.67%,2/12),the difference was statistically significant(P<0.05).Conclusion Mid-term PET/CT based visual analysis Deauville 5-point scale and semi-quantitative analysisΔSUVmax met

关 键 词：弥漫大B细胞淋巴瘤 PET/CT Deauville五分法 ΔSUVmax法 

分 类 号：R814.42[医药卫生—影像医学与核医学]