矽肺合并系统性硬化症诊治研究进展  

Progress in diagnosis and treatment of silicosis complicated with systemic sclerosis

作　　者：张光江 周杭棋 马丽丽(综述) 纪伟(审校) Zhang Guangjiang;Zhou Hangqi;Ma Lili;Ji Wei(Department of Rheumatology and Immunology,Affiliated Hospital of Nanjing University of Chinese Medicine/Jiangsu Hospital of Traditional Chinese Medicine,Jiangsu Province,Nanjing 210029,China)

机构地区：[1]南京中医药大学附属医院/江苏省中医院风湿免疫科,210029

出　　处：《疑难病杂志》2024年第4期500-503,508,共5页Chinese Journal of Difficult and Complicated Cases

基　　金：江苏省中医药科技发展计划项目(ZD202218);江苏省研究生实践创新计划项目(SJCX23_0881)。

摘　　要：矽肺是职业病中难治愈、预后差、病死率较高的一种职业病。系统性硬化症是一种慢性自身免疫性疾病,其特征是自身抗体产生、小血管病变和纤维母细胞功能障碍,导致细胞外基质不受控制的沉积。矽肺合并系统性硬化症临床称为伊拉斯谟(Erasmus)综合征,其发病机制仍未阐明,目前尚无形成统一诊疗规范,文章对近年来矽肺合并系统性硬化症的国际国内相关研究进行综述,为矽肺合并系统性硬化症的诊疗提供借鉴。Silicosis is a kind of occupational disease which is difficult to cure,has poor prognosis and high fatality rate.Systemic sclerosis is a chronic autoimmune disease characterized by autoantibody production,small vessel lesions,and fibroblast dysfunction,leading to uncontrolled deposition of extracellular matrix.Silicosis complicated with systemic sclerosis is clinically known as Erasmus syndrome,the pathogenesis of which has not yet been clarified,and no unified diagnosis and treatment norms have been formed.This article reviews relevant international and domestic studies on silicosis complicated with systemic sclerosis in recent years,providing reference for the diagnosis and treatment of silicosis complicated with systemic sclerosis.

关 键 词：矽肺 系统性硬化症 伊拉斯谟综合征 诊断 治疗 研究进展 

分 类 号：R563.9[医药卫生—呼吸系统] R593.2[医药卫生—内科学]