七例儿童结缔组织痣临床及组织病理学分析  

Clinical and histopathological features of 7 cases with childhood connective tissue nevi

作　　者：李倩 张海花 秦琴 刘晓雁[1] 张高磊[1] LI Qian;ZHANG Haihua;QIN Qin;LIU Xiaoyan;ZHANG Gaolei(Capital Institute of Pediatrics,Beijing 100020,China)

机构地区：[1]北京首都儿科研究所附属儿童医院皮肤科,北京100020

出　　处：《中国麻风皮肤病杂志》2024年第5期317-320,共4页China Journal of Leprosy and Skin Diseases

基　　金：国家自然科学基金面上项目(编号:81974473,82073461)。

摘　　要：目的:分析儿童结缔组织痣的临床表现及病理学特征。方法:回顾分析北京首都儿科研究所附属儿童医院皮肤科2018年3月至2022年3月儿童结缔组织痣临床资料。结果:共分析7例患儿,男5例,女2例,平均就诊年龄6.7岁,平均发病年龄2.8岁;平均病程4年;皮损位于大腿4例,腰部1例,臀部1例,腰臀部1例。临床表现4例为色素沉着斑块,3例为色素减退斑块。除1例为伴结节性硬化症者,其余6例不伴其他器官病变;病理分型6例为胶原蛋白型;结节性硬化症患儿的家长拒绝活检。遗传学6例为获得性,1例为遗传性。结论:结缔组织痣患儿平均发病年龄较早,为2.8岁。部位常见于腰骶部和大腿,表现质韧的斑块,皮损未发展至明显的结节,可能与就诊年龄早、病程短有关。以获得性居多,较少具有家族史。病理上以胶原蛋白型为主。患儿伴随其他器官受累需进一步排除相关综合征。Objective:To analyze clinical and histopathological features of connective tissue nevi in children.Methods:Clinical data were collected of connective tissue nevi in Capital Institute of Pediatrics from March 2018 to March 2022,and analyzed retrospectively.Results:The data of 7 children were analyzed,including 5 males and 2 females.The average age at the clinic visit was 6.7 years.The average onset age was 2.8 years.The average duration of lesion was 4 years.Four children's lesions were on the thigh.The other 3 were respectively on the lumbar region,buttock,lumbar region and bottock.The clinical manifestation of the lesions were plaques,4 were pigmented,3 were depigmented.Except 1 child was diagnosed with tuberous sclerosis,the 6 children were without other organ involvement.There were 6 collagen type,and the child with tuberous sclerosis refused the test.Six children were acquired type,1 was hereditary type.Conclusion:The average onset age of children with connective tissue nevi was as early as 2.8 years old.It is common in the lumbosacral and thigh,presenting as tough plaques.It may be related to the early diagnosis and short course of the disease,the skin lesions did not develop into obvious nodules.Very few have family history,and most of them are acquired type.They were mainly collagen type.The CTN children with othe organ involvement need to be ruled out certain syndrome.

关 键 词：结缔组织痣 儿童 临床特征 组织病理特征 

分 类 号：R758.51[医药卫生—皮肤病学与性病学]