TNF-α抑制剂治疗头部脓肿性穿掘性毛囊周围炎一例并文献复习  

Treatment of perifolliculitis capitis abscedens et suffodiens with TNF-αinhibitors:a case report and literature review

作　　者：陈晶 薛晓彤 朱莉 刘红 张福仁[1,2] CHEN Jing;XUE Xiaotong;ZHU Li;LIU Hong;ZHANG Furen(Hospital for Skin Diseases,Shandong First Medical University,Jinan 250022,China;Shandong Provincial Institute of Dermatology and Venereology,Shandong Academy of Medical Sciences,Jinan 250022,China)

机构地区：[1]山东第一医科大学附属皮肤病医院,山东济南250022 [2]山东省皮肤病性病防治研究所,山东济南250022

出　　处：《中国麻风皮肤病杂志》2024年第5期326-329,共4页China Journal of Leprosy and Skin Diseases

基　　金：山东省皮肤性病学临床医学研究中心。

摘　　要：患者,男,45岁。头皮丘疹、结节、脓肿、破溃反复,伴疼痛5年。诊断为头部脓肿性穿掘性毛囊周围炎。经常规治疗效果欠佳,改用阿达木单抗治疗,治疗4个半月后,疼痛显著减轻、结节缩小、炎症缓解、脓液分泌减少/停止。患者继续治疗并随访中。已有文献报道了应用TNF-α抑制剂治疗PCAS的临床疗效。本文对本例患者及既往文献进行了回顾性分析。A 45-year-old male presented with scalp papules,nodules,abscesses,and recurrent ulceration accompanied by pain for 5 years.He was diagnosed with perifolliculitis capitis abscedens et suffodiens.After an unsatisfactory response to conventional treatment,the patient was treated with adalimumab.After four and a half months of treatment,significant alleviation of pain,shrinkage of nodules,resolution of inflammation,and reduction or cessation of purulent discharge were observed.The patient is currently undergoing continuous treatment and follow-up.Some literature has reported on the clinical efficacy of TNF-α inhibitors in treating PCAS.This paper conducts a retrospective analysis of the treatment of the present case and previous literature.

关 键 词：头部脓肿性穿掘性毛囊周围炎 头部解剖性蜂窝织炎 TNF-Α抑制剂 阿达木单抗 

分 类 号：R753.3[医药卫生—皮肤病学与性病学]