克罗米酚联合二甲双胍治疗多囊卵巢综合征的效果及对患者性激素水平的影响  

Curative effect of clomiphene combined with metformin on polycystic ovary syndrome and its influence on sex hormones levels

作　　者：翟一阳[1] 翟俊英[1] 钮红丽[1] Zhai Yiyang;Zhai Junying;Niu Hongli(Department of Reproductive Medicine,Nanyang First People's Hospital,Nanyang 473010,China)

机构地区：[1]南阳市第一人民医院生殖医学科,南阳473010

出　　处：《中国实用医刊》2024年第1期94-97,共4页Chinese Journal of Practical Medicine

摘　　要：目的分析克罗米酚联合二甲双胍治疗多囊卵巢综合征(PCOS)的效果及对患者性激素水平的影响。方法随机对照研究。抽取2020年6月至2022年6月南阳市第一人民医院收治的PCOS患者68例,按随机数字表法分为观察组与对照组,每组34例。对照组采用克罗米酚治疗,观察组在对照组基础上加用二甲双胍治疗。比较两组治疗效果、性激素水平[促黄体生成素(LH)、卵泡刺激素(FSH)、雌二醇(E2)]、促排卵效果、临床症状发生情况、胰岛素抵抗指数(HOMA-IR)及体质指数。结果观察组总有效率(97.06%,33/34)高于对照组(76.47%,26/34),P<0.05。治疗后,观察组LH、FSH水平低于对照组,E2水平高于对照组(P<0.05)。观察组卵泡成熟时间短于对照组,子宫内膜厚度大于对照组(P<0.05)。治疗后,观察组痤疮、月经稀发、体毛增多发生率(5.88%,2/34;8.82%,3/34;.82%,3/34)均低于对照组(23.53%,8/34;29.41%,10/34;32.35%,11/34),P<0.05。治疗后,观察组HOMA-IR水平低于对照组(P<0.05)。治疗后,观察组体质指数低于对照组(P<0.05)。结论克罗米酚联合二甲双胍治疗PCOS效果显著,可改善性激素水平、胰岛素抵抗情况和肥胖情况,显著提高促排卵效果。Objective To analyze the curative effect of clomiphene combined with metformin on polycystic ovary syndrome,and its influence on sex hormones levels.Methods This study was a randomized contr olled trail.A total of 68 patients with polycystic ovary syndrome treated in Nanyang First People’s Hospital from June 2020 to June 2022 were selected,and they were divided into observation group and control group according to random number table method,with 34 cases in each group.The control group was given clomiphene,and the observation group was given metformin based on the treatment of the control group.The efficacy,levels of sex hormones,including luteinizing hormone(LH),follicle-stimulating hormone(FSH)and estradiol(E2),ovulation effect,clinical symptom occurrence,homeostatic model assessment for insulin resistance(HOMA-IR)and body mass index of the two groups were compared.Results The total effective rate of the observation group(97.06%,33/34)was higher than that of the control group(76.47%,26/34),P<0.05.After treatment,levels of LH and FSH in the observation group were lower than those in the control group,while level of E2 in the observation group was higher than that in the control group(P<0.05).The follicle maturation time of the observation group was shorter,and the endometrial thickness was thicker,compared with the control group(P<0.05).After treatment,the incidence of acne,oligomenorrhea and increased body hair in the observation group(5.88%,2/34;8.82%,3/34;8.82%,3/34)were lower than those in the control group(23.53%,8/34;29.41%,10/34;32.35%,11/34),P<0.05.After treatment,HOMA-IR level in the observation group was lower than that in the control group(P<0.05).After treatment,the body mass index of the observation group was lower than that of the control group(P<0.05).Conclusions Clomiphene combined with metformin in the treatment of polycystic ovary syndrome is effective,which can improve the sex hormones levels,insulin resistance and obesity.Moreover,it can significantly improve the effect of ovulation promoti

关 键 词：多囊卵巢综合征 克罗米酚 二甲双胍 

分 类 号：R711.75[医药卫生—妇产科学]